The Fountain of Youth by Targeting Senescent Cells?
Abstract
The potential to reverse aging has long been a tantalizing thought, but has equally been considered mere utopia. Recently, the spotlights have turned to senescent cells as being a culprit for aging. Can these cells be therapeutically eliminated? When so? And is this even safe? Recent developments in the tool box to study senescence have made it possible to begin addressing these questions. It will be especially relevant to identify how senescence impairs tissue rejuvenation and to prospectively design compounds that can both target senescence and stimulate rejuvenation in a safe manner. This review argues that to fulfill this niche, cell-penetrating peptides may provide promising therapeutics. As a candidate approach, the author also highlights the potential of targeting individual FOXO signaling pathways to combat senescence and stimulate tissue rejuventaion.
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During aging, senescent cell accumulation in various tissues promotes chronic inflammation that accelerates age-related dysfunctions.
“During aging, senescent cell accumulation in various tissues promotes chronic inflammation that accelerates age-related dysfunctions [16].”
From Mechanisms and Regulation of Cellular Senescence (2021) · cites this paper as [16]
Senescence is an important contributor to cancer and aging.
“Senescence is an important contributor to cancer and aging, two processes characterized by a time-dependent accumulation of cell damage and dysfunction.”
From Mechanisms and Regulation of Cellular Senescence (2021) · cites this paper as [16]
Senescent cells accumulate in different tissues and organs where they have distinct physiological and pathological functions.
“Senescent cells accumulate in different tissues and organs where they have distinct physiological and pathological functions.”
From Mechanisms and Regulation of Cellular Senescence (2021) · cites this paper as [16]
Cellular senescence occurs not only in vitro but also in various tissues in vivo.
“Cellular senescence occurs not only in vitro (i.e., cell culture models), but also in various tissues in vivo [13,14,15,16].”
From Mechanisms and Regulation of Cellular Senescence (2021) · cites this paper as [16]
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References 96 · Cited by 127
- Authors
- de Keizer, P. L. J.
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2017-01
- Volume
- 23
- Issue
- 1
- Pages
- 6-17
- ISSN
- 1471-4914 (ISSN-L)
- OpenAlex
- W2564651192
- Cited by
- 127
- References
- 96
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 9 · 2023: 10 · 2022: 10 · 2021: 12 · 2020: 15 · 2019: 19 · 2018: 31 · 2017: 10
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- cellular senescence, senolytics, aging reversal, tissue rejuvenation, cell-penetrating peptides, FoxO signaling
- MeSH terms
- Aging, Animals, Humans, Signal Transduction, Cellular Senescence, Forkhead Transcription Factors, Cell-Penetrating Peptides, Molecular Targeted Therapy
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