Glutamine Skipping the Q into Mitochondria
Open accessAbstract
Imported across the plasma membrane by SLC1A5, glutamine has emerged as a metabolic fuel that is catabolized by mitochondrial glutaminase to support tumor growth. The missing link between cytoplasmic and mitochondrial glutamine metabolism is now provided by Yoo et al., identifying the mitochondrial glutamine importer as a variant of SLC1A5.
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α-KG is exported from mitochondria through SLC25A11 to the cytosol and participates in fatty acid biosynthesis and NADH generation.
“In addition, α-KG is exported from mitochondria through SLC25A11 to the cytosol21 and then participates in fatty acid biosynthesis and NADH generation22 (Fig. 1).”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [21]
Mitochondrial glutamate can be exported from mitochondria to the cytosol through SLC25A18 and SLC25A22 transporters.
“Mitochondrial glutamate generated via these catabolic pathways can be exported from mitochondria to the cytosol through the SLC25A18 and SLC25A22 transporters21”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [21]
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References 10 · Cited by 19
- Authors
- Stine, Z. E., & Dang, C. V.
- Affiliations
- The Wistar Institute (US)
- Corresponding author
- Dang, Chi V.
- ORCID
- Dang, Chi V.
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2020-01
- Volume
- 26
- Issue
- 1
- Pages
- 6-7
- ISSN
- 1471-4914 (ISSN-L)
- PMC
- PMC7758675
- OpenAlex
- W2994736457
- Cited by
- 19
- References
- 10
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 2
- FWCI
- 0.63
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- glutamine, SLC1A5, glutamine catabolism, cancer metabolism, plasma membrane transport
- MeSH terms
- Animals, Cytoplasm, Glutaminase, Glutamine, Humans, Mitochondria, Neoplasms, Amino Acid Transport System ASC, Cell Proliferation
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