Organoids, Where We Stand and Where We Go
Abstract
Organoid cultures hold the promise of transforming basic and clinical research. Here, we provide a storyline of the highlights and breakthroughs that have an impact in present clinical research. We also discuss the bottlenecks that delay their full exploitation for the next generation of biomedical research.
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3D culture systems and organoids are not yet capable of reconstructing the complex diversity of hepatocyte identity and metabolic zonation found in a liver.
“Moreover, 3D culture systems and organoids are not yet capable of reconstructing the complex diversity of hepatocyte identity and metabolic zonation found in a liver.171”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [171]
Cites
Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients
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Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver
Huch, M., Gehart, H., van Boxtel, R., Hamer, K., Blokzijl, F., Verstegen, M. M. A., Ellis, E., van Wenum, M., Fuchs, S. A., de Ligt, J., et al. (2015) · Cell · doi:10.1016/j.cell.2014.11.050 · Cited by 1,619 · see citing works
Self-citationEiraku, M., Watanabe, K., Matsuo-Takasaki, M., Kawada, M., Yonemura, S., Matsumura, M., Wataya, T., Nishiyama, A., Muguruma, K., & Sasai, Y. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.09.002 · Cited by 1,522 · see citing works
Generation of Functional Human 3D Cortico-Motor Assembloids
Andersen, J., Revah, O., Miura, Y., Thom, N., Amin, N. D., Kelley, K. W., Singh, M., Chen, X., Thete, M. V., Walczak, E. M., et al. (2020) · Cell · doi:10.1016/j.cell.2020.11.017 · Cited by 593 · see citing works
Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis
Berkers, G., van Mourik, P., Vonk, A. M., Kruisselbrink, E., Dekkers, J. F., de Winter-de Groot, K. M., Arets, H. G. M., Marck-van der Wilt, R. E. P., Dijkema, J. S., Vanderschuren, M. M., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.01.068 · Cited by 310 · see citing works
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Distinct hepatocyte identities in liver homeostasis and regeneration
Chen, F., Schönberger, K., & Tchorz, J. S. (2023) · JHEP Reports · doi:10.1016/j.jhepr.2023.100779 · Cited by 30 · see citing works
- Authors
- Kaluthantrige Don, F., & Huch, M.
- Affiliations
- Max Planck Institute of Molecular Cell Biology and Genetics (DE)
- Corresponding author
- Huch, Meritxell
- ORCID
- Huch, Meritxell
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2021-05
- Volume
- 27
- Issue
- 5
- Pages
- 416-418
- ISSN
- 1471-4914 (ISSN-L)
- OpenAlex
- W3156585165
- Cited by
- 32
- References
- 5
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 8 · 2023: 6 · 2022: 3 · 2021: 4
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Trends in Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Max-Planck-Gesellschaft
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- organoids, organoid culture, 3D cell culture, research bottlenecks
- MeSH terms
- Humans, Organoids, Organ Transplantation, Cell Culture Techniques, Biomedical Research, Tissue Culture Techniques
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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