Coenzyme Q10 Prevents Accelerated Cardiac Aging in a Rat Model of Poor Maternal Nutrition and Accelerated Postnatal Growth
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Studies in human and animals have demonstrated that nutritionally induced low birth-weight followed by rapid postnatal growth increases the risk of metabolic syndrome and cardiovascular disease. Although the mechanisms underlying such nutritional programming are not clearly defined, increased oxidative-stress leading to accelerated cellular aging has been proposed to play an important role. Using an established rodent model of low birth-weight and catch-up growth, we show here that post-weaning dietary supplementation with coenzyme Q10, a key component of the electron transport chain and a potent antioxidant rescued many of the detrimental effects of nutritional programming on cardiac aging. This included a reduction in nitrosative and oxidative-stress, telomere shortening, DNA damage, cellular senescence and apoptosis. These findings demonstrate the potential for postnatal antioxidant intervention to reverse deleterious phenotypes of developmental programming and therefore provide insight into a potential translatable therapy to prevent cardiovascular disease in at risk humans.
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CoQ10 may prevent cardiac aging, metabolic syndrome, and cardiovascular disorders when administered post-weaning to a rat model, mediated by reduction of ROS and RNS, senescence, and apoptosis.
“Moreover, CoQ10 may prevent cardiac aging, metabolic syndrome, and cardiovascular disorders when administered post-weaning to a rat model that mimics these conditions, and this improvement is mediated by the reduction of ROS and RNS, senescence, and apoptosis [58].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [58]
Coenzyme Q10, SkQ1, mitoquinone and methylene blue are among mitochondria targeted antioxidants exerting a role in counteracting OS-induced senescence, with CoQ10 being the most studied.
“Coenzyme Q10 (CoQ10), SkQ1 (a.k.a. visomitin), mitoquinone (MitoQ) and methylene blue are among the mitochondria targeted antioxidants exerting a role in counteracting OS-induced senescence, with CoQ10 being the most studied (Table 1 and Table 2) [57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [58]
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References 82 · Cited by 47
- Authors
- Tarry-Adkins, J. L., Blackmore, H. L., Martin-Gronert, M. S., Fernandez-Twinn, D. S., McConnell, J. M., Hargreaves, I. P., Giussani, D. A., & Ozanne, S. E.
- Affiliations
- University of Cambridge (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- Venue
- Molecular Metabolism
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 2
- Issue
- 4
- Pages
- 480-490
- ISSN
- 2212-8778 (ISSN-L)
- PMC
- PMC3854989
- OpenAlex
- W2101176463
- Cited by
- 47
- References
- 82
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 2 · 2019: 3 · 2018: 6 · 2017: 4 · 2016: 9 · 2015: 7 · 2014: 3
- FWCI
- 5.91
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Molecular Metabolism (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- The British Heart Foundation and the Medical Research Council
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- coenzyme Q10, cardiac aging, low birth weight, catch-up growth, maternal nutrition, developmental programming, oxidative stress, nitrosative stress, telomere shortening, DNA damage, cellular senescence, apoptosis, antioxidant supplementation, cardiovascular disease prevention, metabolic syndrome
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