Adipokines – removing road blocks to obesity and diabetes therapy
Open accessAbstract
Prevention of obesity and therapeutic weight loss interventions have provided only limited long term success. Therefore there is an urgent need to develop novel pharmacological treatment strategies, which target mechanisms underlying positive energy balance, excessive fat accumulation and adverse fat distribution. Adipokines may have potential for future pharmacological treatment strategies of obesity and metabolic diseases, because they are involved in the regulation of appetite and satiety, energy expenditure, endothelial function, blood pressure, insulin sensitivity, adipogenesis, fat distribution and insulin secretion and others. There are important road blocks on the way from an adipokine candidate to the clinical use a therapeutic compound. Such road blocks include an incomplete understanding of the mechanism of action, resistance to a specific adipokine, side effects of the adipokine and others. This review focuses on the potential of selected adipokines as therapeutic tools or targets and discusses important road blocks, which currently prevent their clinical use.
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Numerous families of secreted signaling molecules bearing the suffix "-kines," such as myokines, osteokines, adipokines, and hepatokines, have been identified in more recent times.
“Hormones were identified and subsequently leveraged for use as therapeutics throughout the 20th century but it is only in more recent times that numerous families of secreted signaling molecules bearing the suffix “‐kines” such as myokines, 243 osteokines, adipokines, 244 and hepatokines 245 have been identified. 242”
From The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments (2022) · cites this paper as [244]
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References 100 · Cited by 273
- Authors
- Blüher, M.
- Affiliations
- Leipzig University (DE)
- Corresponding author
- Blüher, Matthias
- ORCID
- Blüher, Matthias
- Venue
- Molecular Metabolism
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 3
- Issue
- 3
- Pages
- 230-240
- ISSN
- 2212-8778 (ISSN-L)
- PMC
- PMC3986498
- OpenAlex
- W1970117178
- Cited by
- 273
- References
- 100
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 13 · 2023: 20 · 2022: 20 · 2021: 26 · 2020: 20 · 2019: 22 · 2018: 26 · 2017: 22 · 2016: 31 · 2015: 35 · 2014: 15
- FWCI
- 4.51
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecular Metabolism (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- adipokines, obesity, diabetes mellitus, pharmacotherapy, therapeutic target, energy balance, insulin sensitivity, satiety, adipogenesis, body fat distribution, drug resistance, adverse effects, clinical translation
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