Testing the carbohydrate-insulin model in mice: the importance of distinguishing primary hyperinsulinemia from insulin resistance and metabolic dysfunction
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Testing the carbohydrate-insulin model in mice: The importance of distinguishing primary hyperinsulinemia
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In animals, high- compared with low-GI diets increase adiposity independently of energy intake, in association with lower physical activity level.
“In animals, high- compared with low-GI diets increase adiposity independently of energy intake, in association with lower physical activity level (45, 93–96).”
From The carbohydrate-insulin model: A physiological perspective on the obesity pandemic (2021) · cites this paper as [94]
Laboratory high-fat diets often contain high amounts of sugar and exceptionally high saturated fat.
“Often, high-fat diets used in the laboratory contain not only high amounts of sugar, but also exceptionally high saturated fat content (94)”
From The carbohydrate-insulin model: A physiological perspective on the obesity pandemic (2021) · cites this paper as [94]
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References 10 · Cited by 18
- Authors
- Ludwig, D. S., Ebbeling, C. B., Bikman, B. T., & Johnson, J. D.
- Affiliations
- Boston Children's Hospital (US)
- Brigham Young University (US)
- University of British Columbia (CA)
- Corresponding author
- Ludwig, David S.
- Venue
- Molecular Metabolism
- Publisher
- Elsevier BV
- Published
- 2020-05
- Volume
- 35
- Pages
- 100960
- ISSN
- 2212-8778 (ISSN-L)
- PMC
- PMC7191247
- OpenAlex
- W3006086139
- Cited by
- 18
- References
- 10
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 1
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecular Metabolism (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- insulin resistance, metabolic dysfunction, mice
- MeSH terms
- Nutrients, Animals, Body Weight, Carbohydrates, Hyperinsulinism, Insulin, Insulin Resistance, Adiposity, Mice
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