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Cited by 166

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Intercepting pelvic cancer in the distal fallopian tube: Theories and realities

Open access
Crum, Christopher P.·2009·Molecular Oncology

Abstract

The pathogenesis of high‐grade serous carcinoma of the ovary has come into sharper focus as closer attention has been paid to the earlier phases of this disease. The study of patients with BRCA mutation has been of particular value, in as much as the examination of prophylactic salpingo‐oophorectomies will reveal an early cancer in approximately 5% of individuals. Recently studies have shown that about 80% of these early carcinomas originate in the distal fallopian tube. This review summarizes the recent data supporting the distal fallopian tube as an important site for serous carcinogenesis, stressing both the presence of a novel precursor (the p53 signature) and the application of this model to all women irrespective of BRCA status. The challenges and unmet needs unmasked by this paradigm shift in ovarian cancer research are discussed.

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Metadata

Authors
Crum, C. P.
Venue
Molecular Oncology
Publisher
Wiley
Published
2009-02-03
Volume
3
Issue
2
Pages
165-170
ISSN
  • 1574-7891 (ISSN-L)
  • 1878-0261
OpenAlex
W2149834266
Cited by
166
References
1
FWCI
17.72
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Intercepting pelvic cancer in the distal fallopian tube: Theories and realities. https://app.cochat.ai/papers/10.1016/j.molonc.2009.01.004
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Crum, C. P. (2009). Intercepting pelvic cancer in the distal fallopian tube: Theories and realities. Molecular Oncology. https://doi.org/10.1016/j.molonc.2009.01.004

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.