The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Intercepting pelvic cancer in the distal fallopian tube: Theories and realities
Open accessAbstract
The pathogenesis of high‐grade serous carcinoma of the ovary has come into sharper focus as closer attention has been paid to the earlier phases of this disease. The study of patients with BRCA mutation has been of particular value, in as much as the examination of prophylactic salpingo‐oophorectomies will reveal an early cancer in approximately 5% of individuals. Recently studies have shown that about 80% of these early carcinomas originate in the distal fallopian tube. This review summarizes the recent data supporting the distal fallopian tube as an important site for serous carcinogenesis, stressing both the presence of a novel precursor (the p53 signature) and the application of this model to all women irrespective of BRCA status. The challenges and unmet needs unmasked by this paradigm shift in ovarian cancer research are discussed.
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Singer, G., Stöhr, R., Cope, L., Dehari, R., Hartmann, A., Cao, D.-F., Wang, T.-L., Kurman, R. J., & Shih, I.-M. (2005) · American Journal of Surgical Pathology · doi:10.1097/01.pas.0000146025.91953.8d · Cited by 408
Cited by
Modeling High-Grade Serous Ovarian Carcinogenesis from the Fallopian Tube
Karst, A. M., Levanon, K., & Drapkin, R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1017300108 · Cited by 280
Metadata
- Authors
- Crum, C. P.
- Venue
- Molecular Oncology
- Publisher
- Wiley
- Published
- 2009-02-03
- Volume
- 3
- Issue
- 2
- Pages
- 165-170
- ISSN
- 1574-7891 (ISSN-L)
- 1878-0261
- OpenAlex
- W2149834266
- Cited by
- 166
- References
- 1
- FWCI
- 17.72
- Type
- journal article
- Language
- en
- Open access
- green
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