RETRACTED: Genotoxicity assessment of cerium oxide nanoparticles in female Wistar rats after acute oral exposure
Abstract
Cerium oxide nanoparticles (CeO2 NPs; nanoceria) have demonstrated excellent potential for commercial use in various arenas, such as in biomedical industry in cosmetics and as a fuel additive. However, limited knowledge exists regarding their potential toxicity. In this study, acute oral toxicity of CeO2 NPs and their microparticles (MPs; bulk) was carried out in female albino Wistar rats. The CeO2 NPs and CeO2 MPs were characterized utilizing transmission electron microscopy (TEM), dynamic light scattering (DLS) and laser Doppler velocimetry (LDV) for the size, distribution and surface charge respectively. The genotoxicity studies were conducted using micronucleus test (MNT), comet and chromosomal aberration (CA) assays. Results revealed that at high dose (1000mg/kg bw) CeO2 NPs induced significant DNA damage in peripheral blood leukocytes (PBL) and liver cells, micronucleus formation in bone marrow and blood cells and total cytogenetic changes in bone marrow. However, significant genotoxicity was not observed at 500 and 100mg/kg bw of CeO2 NPs. The findings from biochemical assays depicted significant alterations in ALP and LDH activity in serum and GSH content in liver, kidneys and brain only at the high dose of CeO2 NPs. Tissue biodistribution of both particles was analyzed by inductively coupled plasma optical emission spectrometer (ICP-OES). Bioaccumulation of nanoceria in all tissues was significant and dose-, time- and organ-dependent. Moreover, CeO2 NPs exhibited higher tissue distribution along with greater clearance in large fractions through urine and feces than CeO2 bulk, whereas, maximum amount of micro-sized CeO2 got excreted in feces. The histopathological examination documented alterations in the liver due to exposure with CeO2 NPs only. Hence, the results suggest that bioaccumulation of CeO2 NPs may induce genotoxic effects. However, further research on long term fate and adverse effects of CeO2 NPs is warranted.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Systemic genotoxic effects were reported after single and repeated oral administration of CeO2.
“systemic genotoxic effects were reported after single and repeated oral administration of CeO2 [49, 50]”
From Effects from a 90-day inhalation toxicity study with cerium oxide and barium sulfate nanoparticles in rats (2017) · cites this paper as [50]
The citation lists haven’t been fetched yet
References 59 · Cited by 64
- Authors
- Kumari, M., Kumari, S. I., Kamal, S. S. K., & Grover, P.
- Affiliations
- Indian Institute of Chemical Technology (IN)
- Defence Metallurgical Research Laboratory (IN)
- Corresponding author
- Grover, Paramjit
- Venue
- Mutation Research/Genetic Toxicology and Environmental Mutagenesis
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 775-776
- Pages
- 7-19
- ISSN
- 1383-5718 (ISSN-L)
- OpenAlex
- W2046839162
- Cited by
- 64
- References
- 59
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 4 · 2022: 8 · 2021: 2 · 2020: 7 · 2019: 8 · 2018: 13 · 2017: 9 · 2016: 6 · 2015: 4
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- closed
- Locations
- Mutation Research/Genetic Toxicology and Environmental Mutagenesis (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Asian Office of Aerospace Research and Development (FA2386-11-1-4085)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Keywords
- cerium oxide nanoparticles, genotoxicity, acute oral toxicity, DNA damage, micronuclei, chromosomal abnormalities, bioaccumulation, tissue distribution, liver histopathology, enzyme activity, microparticles
- MeSH terms
- Administration, Oral, Animals, Body Weight, Cerium, Chromosome Aberrations, Dose-Response Relationship, Drug, Female, Organ Specificity, Organ Size, Particle Size, Tissue Distribution, Rats, Wistar, Rats, Metal Nanoparticles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
