Investigation on the properties of linear PLA-poloxamer and star PLA-poloxamine copolymers for temporary biomedical applications
Open accessAbstract
The objective of this work was to develop and study new biodegradable thermoplastics with improved mechanical properties for potential use as temporary implantable biomaterials. Linear poloxamer and star-shaped poloxamine have been used as macroinitiators for the ring-opening polymerization (ROP) of lactide to yield high molecular weight PLA-based thermoplastic block copolymers. The influence of the nature of the macroinitiator, PLA crystallinity and initial molecular weight on the copolymers properties was investigated by performing a 7-week degradation test in PBS. The evaluation of water uptakes and molecular weights during the degradation pointed out an early hydrolytic degradation of the 100-kg∙mol(-1) copolymers compared to the 200-kg∙mol(-1) ones (molecular weight decrease of ca. 40% and 20%, respectively). A dramatic loss of tensile mechanical properties was also observed for the 100-kg∙mol(-1) copolymers, whereas the 200-kg∙mol(-1) copolymers showed stable or even slightly improved properties with Young's moduli around 500 MPa and yield strains around 3% to 4%. Finally, the cytocompatibility of the more stable 200 kg∙mol(-1) copolymers was confirmed by murine mesenchymal stem cells (MSCs) culture.
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For amorphous PLA, there is a period in the earlier stages of degradation during which Young's modulus and tensile strength remain constant before decreasing.
“However, many authors observed that it exists a period, especially for amorphous PLA, in the earlier stages of degradation, for which Young's modulus and tensile strength remain constant before decreasing (Tsuji, 2002; Karjalainen et al., 1996; Leroy et al., 2013).”
From Mechanical behaviour׳s evolution of a PLA-b-PEG-b-PLA triblock copolymer during hydrolytic degradation (2016) · cites this paper as Leroy et al., 2013
Section 3.5 (page unavailable) reports that, for the studied PLA-based copolymers, Young’s modulus stayed stable and stress at failure remained in the same range early in degradation, before mechanical properties decreased. It does not establish that pattern specifically for amorphous PLA; stress at failure also increased slightly during the initial period rather than remaining constant. (LLM, conf=0.86)
Experimental — accuracy not yet measuredThe induction period in mass loss is commonly observed during degradation of aliphatic polyesters and is due to the difficulty for degraded chains to diffuse out of the sample.
“This induction period is commonly observed during the degradation of aliphatic polyesters and is due to the dif fi culty, At fi rst, for the degraded chains to diffuse out of the sample (Leroy et al., 2013; Li et al., 1990).”
From Mechanical behaviour׳s evolution of a PLA-b-PEG-b-PLA triblock copolymer during hydrolytic degradation (2016) · cites this paper as Leroy et al., 2013
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References 37 · Cited by 22
Research works printed but not linked: 1
- P. Aizawa, G. Karlsson, C. Benemar, V. Segl, K. Martinelle, E. Lindner, R. Smith, Ef- fect of different materials used in bioreactor equipments on cell growth of human embryonic kidney (HEK293) cells cultivated in a protein-free medium cell tech- nology for cell products, Springer, Netherlands, 2007. 459-462.
- Authors
- Leroy, A., Pinese, C., Bony, C., Garric, X., Noël, D., Nottelet, B., & Coudane, J.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Corresponding author
- Nottelet, Benjamin
- ORCID
- Venue
- Materials Science and Engineering C
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 33
- Issue
- 7
- Pages
- 4133-4139
- ISSN
- 0928-4931 (ISSN-L)
- OpenAlex
- W2006148138
- Cited by
- 22
- References
- 37
- Citations by year
- 2025: 1 · 2022: 1 · 2021: 1 · 2020: 5 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 7 · 2015: 1
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Materials Science and Engineering C (publishedVersion, other-oa)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by-nc-nd)
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › Magnesium Alloys: Properties and Applications
- Keywords
- polylactic acid, poloxamer, poloxamine, star block copolymers, linear block copolymers, ring-opening polymerization, macroinitiator, biodegradable thermoplastics, temporary implants, hydrolytic degradation, molecular weight effects, tensile properties, water absorption, cytocompatibility, mesenchymal stem cells
- MeSH terms
- Animals, Cell Line, Chromatography, Gel, Ethylenediamines, Materials Testing, Microscopy, Fluorescence, Molecular Weight, Polyesters, Polymers, Temperature, Water, Cell Death, Lactic Acid, Poloxamer, Biomedical Technology, Cell Proliferation, Mice, Mechanical Phenomena, Mesenchymal Stem Cells
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