Relevance of PEG in PLA-based blends for tissue engineering 3D-printed scaffolds
Open accessAbstract
Achieving high quality 3D-printed structures requires establishing the right printing conditions. Finding processing conditions that satisfy both the fabrication process and the final required scaffold properties is crucial. This work stresses the importance of studying the outcome of the plasticizing effect of PEG on PLA-based blends used for the fabrication of 3D-direct-printed scaffolds for tissue engineering applications. For this, PLA/PEG blends with 5, 10 and 20% (w/w) of PEG and PLA/PEG/bioactive CaP glass composites were processed in the form of 3D rapid prototyping scaffolds. Surface analysis and differential scanning calorimetry revealed a rearrangement of polymer chains and a topography, wettability and elastic modulus increase of the studied surfaces as PEG was incorporated. Moreover, addition of 10 and 20% PEG led to non-uniform 3D structures with lower mechanical properties. In vitro degradation studies showed that the inclusion of PEG significantly accelerated the degradation rate of the material. Results indicated that the presence of PEG not only improves PLA processing but also leads to relevant surface, geometrical and structural changes including modulation of the degradation rate of PLA-based 3D printed scaffolds.
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This type of material could be adjusted for 3D printing technology, and thus achieve the engineering of patient-tailored bone grafts.
“It means that this type of material could be adjusted for 3D printing technology, and thus achieve the engineering of patient-tailored bone grafts [173,174,175].”
From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [174]
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Poly (lactic acid) blends: Processing, properties and applications
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Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review
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- Authors
- Serra, T., Ortiz-Hernandez, M., Engel, E., Planell, J. A., & Navarro, M.
- Affiliations
- Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (ES)
- Corresponding author
- Navarro, Melba
- Venue
- Materials Science and Engineering: C
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 38
- Pages
- 55-62
- ISSN
- 0928-4931 (ISSN-L)
- OpenAlex
- W2039455261
- Cited by
- 206
- References
- 3
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 19 · 2023: 16 · 2022: 13 · 2021: 28 · 2020: 17 · 2019: 24 · 2018: 20 · 2017: 18 · 2016: 23 · 2015: 9 · 2014: 4
- FWCI
- 6.39
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by-nc-nd
- Locations
- Materials Science and Engineering C (publishedVersion)
- PubMed (publishedVersion)
- UPCommons institutional repository (Universitat Politècnica de Catalunya) (acceptedVersion, cc-by-nc-nd)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (submittedVersion, cc-by-nc-nd)
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Engineering › Automotive Engineering › Additive Manufacturing and 3D Printing Technologies
- Keywords
- polyethylene glycol, polylactic acid, 3D-printed scaffolds, tissue engineering scaffolds, plasticization, wettability, surface topography, elastic modulus, scaffold degradation, mechanical properties, polymer blends
- MeSH terms
- Interferometry, Microscopy, Electron, Scanning, Polyesters, Polyethylene Glycols, Polymers, Temperature, Porosity, Microscopy, Atomic Force, Lactic Acid, Tissue Engineering, Tissue Scaffolds, Mechanical Phenomena
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