Zirconium amine tris(phenolate): A more effective initiator for biomedical lactide
Open accessAbstract
Here a zirconium amine tris(phenolate) is used as the initiator for the production of polylactide for biomedical applications, as a replacement for a tin initiator (usually tin octanoate). The ring opening polymerization (ROP) was carried out in the melt at 130°C. The zirconium-catalyzed PLA (PLA-Zr) required 30min, resulting in a polydispersity index (PDI) of 1.17, compared to 1h and PDI=1.77 for tin-catalyzed PLA (PLA-Sn). PLA-Zr and PLA-Sn supported osteosarcoma cell (MG63) culture to the same extent (cell number, morphology, extracellular matrix production and osteogenic function) until day 14 when the PLA-Zr showed increased cell number, overall extracellular matrix production and osteogenic function. To conclude, the reduction in reaction time, controllable microstructure and biologically benign nature of the zirconium amine tris(phenolate) initiator shows that it is a more effective initiator for ROP of polylactide for biomedical applications.
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References 34 · Cited by 23
- Authors
- Jones, M. D., Wu, X., Chaudhuri, J., Davidson, M. G., & Ellis, M. J.
- Affiliations
- University of Bath (GB)
- Corresponding author
- Ellis, Marianne J.
- Venue
- Materials Science and Engineering: C
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 80
- Pages
- 69-74
- ISSN
- 0928-4931 (ISSN-L)
- OpenAlex
- W2599170140
- Cited by
- 23
- References
- 34
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 4 · 2022: 7 · 2021: 2 · 2020: 2 · 2019: 2 · 2017: 1
- FWCI
- 0.49
- Type
- journal article
- Language
- en
- Open access
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Materials Science and Engineering C (publishedVersion)
- PubMed (publishedVersion)
- Pure (University of Bath) (publishedVersion, cc-by-nc-nd)
- The University of Bath Online Publications Store (The University of Bath) (submittedVersion, cc-by-nc-nd)
- Funders
- University of Bath
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Chemical Engineering › Process Chemistry and Technology › Carbon dioxide utilization in catalysis
- Keywords
- polylactic acid, lactide ring-opening polymerization, biodegradable polymers, osteogenic differentiation, MG-63 cells, extracellular matrix synthesis, polymer microstructure, biocompatibility
- MeSH terms
- Amines, Dioxanes, Polyesters, Zirconium, Polymerization
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