Microalgae-Based Bioactive Hydrogel Loaded with Quorum Sensing Inhibitor Promotes Infected Wound Healing
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A BBR-Sp gel loaded with berberine in living S. platensis and carboxymethyl chitosan/sodium alginate under laser irradiation constantly released BBR and produced ROS, resulting in synergistic quorum sensing inhibition against MRSA-combined chemo-photodynamic therapy.
“Under laser irradiation, the BBR-Sp gel could constantly release BBR and produce ROS, resulting in a synergistic quorum sensing inhibition against methicillin-resistant S. aureus (MRSA)-combined chemo-photodynamic therapy.”
From Emerging Applications of Chlorella sp. and Spirulina (Arthrospira) sp. (2023) · cites this paper as [166]
The BBR-Sp gel relieved hypoxia, destroyed biofilm formation, down-regulated virulence factors, and accelerated MRSA-infected diabetic wound healing in mice by promoting angiogenesis, skin regeneration, and suppressing inflammation.
“The BBR-Sp gel accelerated MRSA-infected diabetic wound healing in mice by promoting angiogenesis, skin regeneration, and suppressing the inflammatory response.”
From Emerging Applications of Chlorella sp. and Spirulina (Arthrospira) sp. (2023) · cites this paper as [166]
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References 62 · Cited by 165
- Authors
- Hu, H., Zhong, D., Li, W., Lin, X., He, J., Sun, Y., Wu, Y., Shi, M., Chen, X., Xu, F., & Zhou, M.
- Affiliations
- Second Affiliated Hospital of Zhejiang University (CN)
- Zhejiang University (CN)
- National University of Singapore (SG)
- Corresponding author
- Chen, Xiaoyuan
- Xu, Feng
- Zhou, Min
- Venue
- Nano Today
- Publisher
- Elsevier BV
- Published
- 2022-02
- Volume
- 42
- Pages
- 101368
- ISSN
- 1748-0132 (ISSN-L)
- OpenAlex
- W4200475698
- Cited by
- 165
- References
- 62
- Citations by year
- 2026: 37 · 2025: 42 · 2024: 46 · 2023: 31 · 2022: 9
- FWCI
- 6.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nano Today (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- quorum sensing inhibition, infected wound healing, berberine, Spirulina platensis, carboxymethyl chitosan, sodium alginate, methicillin-resistant Staphylococcus aureus, biofilm eradication, photodynamic therapy, chemo-photodynamic therapy, diabetic wound healing, virulence factors, antimicrobial resistance, angiogenesis, skin regeneration
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