Lipoprotein lipase and endothelial lipase expression in mouse brain: regional distribution and selective induction following kainic acid-induced lesion and focal cerebral ischemia
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Lipoprotein and endothelial lipases are members of the triglyceride lipase gene family. These genes are expressed in the brain, where the encoded proteins are fulfilling functions that have yet to be elucidated. In this study, we examined the distribution of their respective mRNAs in the C57BL/6 mouse brain by in situ hybridization. In control mice, we observed widespread expression of lipoprotein lipase (LPL) mRNA mainly in pyramidal cells of the hippocampus (CA1, CA2 and CA3 areas), in the striatum and in several cortical areas. Endothelial lipase (EL) mRNA expression was restricted to CA3 pyramidal cells of the hippocampus, to ependymal cells in the ventral part of the third ventricle and to some cortical cell layers. To gain insight into the role played by lipases in the brain, neurodegeneration was induced by intraperitoneal injection of kainic acid (KA) or by occlusion of the middle cerebral artery (MCA). Upon injection of KA, a rapid increase in EL mRNA expression was observed in the piriform cortex, hippocampus, thalamus and neocortex. However, the levels of LPL mRNA were unaffected by KA injection. Remarkably, after focal cerebral ischemia, the expression of EL was unaffected whereas a dramatic increase in LPL expression was observed in neocortical areas of the lesioned side of the brain. These results show that LPL and EL transcripts are selectively upregulated in function of the type of brain injury. LPL and EL could thus fulfill a function in the pathophysiologica…
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Microglial LPL expression has been implicated in brain development, damage, and disease.
“Moreover, microglial LPL expression has been implicated in brain development, damage, and disease [25,26,27].”
From Lipoprotein Lipase Regulates Microglial Lipid Droplet Accumulation (2021) · cites this paper as [25]
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- Authors
- Paradis, É., Clavel, S., Julien, P., Murthy, M. R. V., de Bilbao, F., Arsenijevic, D., Giannakopoulos, P., Vallet, P., & Richard, D.
- Affiliations
- Université Laval (CA)
- ETH Zurich (CH)
- Centre Hospitalier Universitaire Vaudois (CH)
- University Hospital of Geneva (CH)
- Corresponding author
- Richard, D
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 2004-03
- Volume
- 15
- Issue
- 2
- Pages
- 312-325
- ISSN
- 0969-9961 (ISSN-L)
- OpenAlex
- W2042880112
- Cited by
- 67
- References
- 57
- Citations by year
- 2024: 3 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 4 · 2016: 1 · 2015: 5 · 2014: 4 · 2013: 4 · 2012: 4
- FWCI
- 3.26
- Type
- journal article
- Language
- en
- Open access
- green
- doaj.org
- Licence
- Locations
- Neurobiology of Disease (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- lipoprotein lipase, endothelial lipase, brain mRNA expression, regional distribution, focal cerebral ischemia, hippocampus, striatum, piriform cortex, neocortex, neurodegeneration, brain injury response
- MeSH terms
- Animals, Brain, Cerebral Cortex, Cerebral Infarction, Brain Ischemia, Corpus Striatum, Disease Models, Animal, Hippocampus, Kainic Acid, Lipase, Lipoprotein Lipase, Male, Mice, Inbred C57BL, Nerve Degeneration, Neurotoxins, Reaction Time, RNA, Messenger, Up-Regulation, Gene Expression Regulation, Enzymologic, Pyramidal Cells, Infarction, Middle Cerebral Artery, Mice
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