Alzheimer pathology disorganizes cortico-cortical circuitry: direct evidence from a transgenic animal model

Delatour, B; Blanchard, V; Pradier, L; Duyckaerts, C

doi:10.1016/j.nbd.2004.01.008

Alzheimer pathology disorganizes cortico-cortical circuitry: direct evidence from a transgenic animal model

It has been proposed that Alzheimer disease (AD) is associated with a "disconnection syndrome" due to the gradual loss of morphological and functional integrity of cortico-cortical pathways. This hypothesis derives from indirect neuropathological observations, but definitive evidence that AD prim…