Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses

Almeida, Claudia G., Tampellini, Davide, Takahashi, Reisuke H., Greengard, Paul, Lin, Michael T., Snyder, Eric M., Gouras, Gunnar K.·2005·Neurobiology of Disease

DOI 10.1016/j.nbd.2005.02.008

Cited by (398)

Items 201–300 of 398

Neurophysiological assessment of neural network plasticity and connectivity: Progress towards early functional biomarkers for disease interception therapies in Alzheimer’s disease
Callum Walsh, Wilhelmus H. I. M. Drinkenburg, Abdallah Ahnaou · 2016 · Neuroscience & Biobehavioral Reviews
Synaptic dysfunction in Alzheimer's disease: From the role of amyloid β-peptide to the α-secretase ADAM10
Stefano Musardo, Elena E. Marcello · 2017 · European Journal of Pharmacology
RPS23RG1 Is Required for Synaptic Integrity and Rescues Alzheimer’s Disease–Associated Cognitive Deficits
Dongdong Zhao, Jian Meng, Yingjun Zhao, Yuanhui Huo, Yan Liu, Naizhen Zheng, Muxian Zhang, Yue Gao, Zhicai Chen, Hao Sun et al. · 2018 · Biological Psychiatry
The Acute Effects of Amyloid-Beta1–42 on Glutamatergic Receptor and Transporter Expression in the Mouse Hippocampus
Jason H. Y. Yeung, Thulani Hansika Palpagama, Warren Perry Tate, Katie Peppercorn, Henry John Waldvogel, Richard L. M. Faull, Andrea Kwakowsky · 2020 · Frontiers in Neuroscience
β-Amyloid Oligomers Affect the Structure and Function of the Postsynaptic Region: Role of the Wnt Signaling Pathway
Margarita C. Dinamarca, Marcela Colombres, Waldo F. Cerpa, Christian Bonansco, Nibaldo C. Inestrosa · 2008 · Neurodegenerative Diseases
LPYFDa Neutralizes Amyloid-β-Induced Memory Impairment and Toxicity
Ivica Granic, Marcelo F. Masman, Cornelis Kees Mulder, Ingrid M. Nijholt, Pieter Naudé, Ammerins de Haan, Emőke Borbély, Botond Penke, Paul G.M. Luiten, Ulrich L.M. Eisel · 2010 · Journal of Alzheimer s Disease
Mutant Presenilin 1 Alters Synaptic Transmission in Cultured Hippocampal Neurons
Christina Priller, Ilse Dewachter, Neville Vassallo, Sandra Paluch, Claudia Pace, Hans A. Kretzschmar, Fred VAN LEUVEN, Jochen Wolfgang Herms · 2006 · Journal of Biological Chemistry
A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer’s disease
Jia Luo, Sue Lee, Lawren A. VandeVrede, Zhihui Qin, Manel Ben Aissa, John Larson, Andrew F. Teich, Ottavio Arancio, Yohan D’Souza, Ahmed Elharram et al. · 2016 · Molecular Neurodegeneration
Significant structural but not physiological changes in cortical neurons of 12-month-old Tg2576 mice
Anne B. Rocher, Michael S. Kinson, Jennifer Irene Luebke · 2008 · Neurobiology of Disease
Far infrared light irradiation enhances Aβ clearance via increased exocytotic microglial ATP and ameliorates cognitive deficit in Alzheimer’s disease-like mice
Qingyong Li, Jun Peng, Yuelian Luo, Jiaxin Zhou, Tailin Li, Lin Sen Cao, Shuling Peng, Zhiyi Zuo, Zhi Wang · 2022 · Journal of Neuroinflammation
Deacidification of endolysosomes by neuronal aging drives synapse loss
Burrinha, Tatiana, Cunha, César, Hall, Michael J., Lopes‐da‐Silva, Mafalda, Seabra, Miguel C., Guimas Almeida, Cláudia · 2023 · Traffic
Altered Protein Palmitoylation as Disease Mechanism in Neurodegenerative Disorders
Jakub Włodarczyk, Raja Bhattacharyya, Kim Doré, Gary P. H. Ho, Dale D. O. Martin, Rebeca Mejı́as, Karin Hochrainer · 2024 · Journal of Neuroscience
Aβ/Amyloid Precursor Protein-Induced Hyperexcitability and Dysregulation of Homeostatic Synaptic Plasticity in Neuron Models of Alzheimer’s Disease
Isak Martinsson, Luís Quintino, Megg G. Garcia, Sabine C Konings, Laura Torres-Garcia, Alexander Svanbergsson, Oliver Stange, Rebecca England, Tomas Deierborg, Jiayi Li et al. · 2022 · Frontiers in Aging Neuroscience
Neuronal loss of NCLX-dependent mitochondrial calcium efflux mediates age-associated cognitive decline
Pooja Jadiya, Henry M. Cohen, Devin W. Kolmetzky, Ashlesha A. Kadam, Dhanendra Tomar, John W. Elrod · 2023 · iScience
Liuwei Dihuang decoction facilitates the induction of long-term potentiation (LTP) in senescence accelerated mouse/prone 8 (SAMP8) hippocampal slices by inhibiting voltage-dependent calcium channels (VDCCs) and promoting N-methyl-d-aspartate receptor (NMDA) receptors
Yan You Huang, Heping Zhang, Sheng Yang, Haifa Qiao, Wenxia Zhou, Yongxiang Zhang · 2012 · Journal of Ethnopharmacology
Real-time nanoscale organization of amyloid precursor protein
Shekhar Kedia, Pratyush Ramakrishna, Pallavi Rao Netrakanti, Mini Jose, Jean‐Baptiste Sibarita, Suhita Nadkarni, Deepak Kumar Nair · 2020 · Nanoscale
PEGylated superparamagnetic iron oxide nanoparticles (SPIONs) ameliorate learning and memory deficit in a rat model of Alzheimer’s disease: Potential participation of STIMs
Mehdi Sanati, Samaneh Aminyavari, Fariba Khodagholi, Mohammad Javad Hajipour, Payam Sadeghi, Marzieh Noruzi, Aynaz Moshtagh, Homayoon Behmadi, Mohammad Sharif Sharifzadeh · 2021 · NeuroToxicology
Engineered neural circuits for modeling brain physiology and neuropathology
Seokyoung Bang, Kyeong Seob Hwang, Sohyeon Jeong, Il‐Joo Cho, Nakwon Choi, Jongbaeg Kim, Hong Nam Kim · 2021 · Acta Biomaterialia
Excitatory synaptic transmission is depressed in cultured hippocampal neurons of APP/PS1 mice
Christina Priller, Gerda Mitteregger, Sandra Paluch, Neville Vassallo, Matthias Staufenbiel, Hans A. Kretzschmar, Mathias Jucker, Jochen Wolfgang Herms · 2008 · Neurobiology of Aging
Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity
Miyamoto, Takashi, Kim, Daniel, Knox, Joseph A., Johnson, Erik, Mucke, Lennart · 2016 · Journal of Biological Chemistry
AMPA Receptor Activation Promotes Non-Amyloidogenic Amyloid Precursor Protein Processing and Suppresses Neuronal Amyloid-β Production
Sarah E. Hoey, Federica Buonocore, Carla J. Cox, Victoria J. Hammond, Michael S. Perkinton, Robert J. Williams · 2013 · PLoS ONE
Elevated PSD-95 Blocks Ion-flux Independent LTD: A Potential New Role for PSD-95 in Synaptic Plasticity
Kim Doré, Roberto Malinow · 2020 · Neuroscience
Age-Dependent Shift of AMPA Receptors From Synapses to Intracellular Compartments in Alzheimer’s Disease: Immunocytochemical Analysis of the CA1 Hippocampal Region in APP/PS1 Transgenic Mouse Model
Alejandro Martín‐Belmonte, Carolina Aguado, Rocío Alfaro‐Ruiz, Makoto Itakura, Ana Esther Moreno‐Martínez, Luis de la Ossa, Elek Molnár, Yugo Fukazawa, Rafael Luján · 2020 · Frontiers in Aging Neuroscience
Pathway-Specific Alteration of Synaptic Plasticity in Tg2576 Mice
Jung Hoon Jung, Kyongman An, Oh Bin Kwon, Hye-Sun Kim, Joung‐Hun Kim · 2011 · Molecules and Cells
Crude Saponins of Panax notoginseng Have Neuroprotective Effects To Inhibit Palmitate-Triggered Endoplasmic Reticulum Stress-Associated Apoptosis and Loss of Postsynaptic Proteins in Staurosporine Differentiated RGC-5 Retinal Ganglion Cells
Dandan Wang, Huazhang Zhu, Shiwei Li, Jia-ming Yang, Yang Xiao, Qiangrong Kang, Chenyang Li, Zhao Yun‐shi, Yong Zeng, Yan Li et al. · 2016 · Journal of Agricultural and Food Chemistry
Centaurin-α1-Ras-Elk-1 Signaling at Mitochondria Mediates β-Amyloid-Induced Synaptic Dysfunction
Erzsebet M. Szatmari, Ana F. Oliveira, Elizabeth Johnson Sumner, Ryohei Yasuda · 2013 · Journal of Neuroscience
DL0410 can reverse cognitive impairment, synaptic loss and reduce plaque load in APP/PS1 transgenic mice
Ranyao Yang, Gang Zhao, Dongmei Wang, Xiao-Cong Pang, Shoubao Wang, Jiansong Fang, Chao Li, Ailin Liu, Song Wu, Guanhua Du · 2015 · Pharmacology Biochemistry and Behavior
Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age
Oeystein Roed Brekk, Alyssa Moskites, Ole Isacson A, Penelope J. Hallett · 2018 · Scientific Reports
Amyloid Precursor Protein (APP) and GABAergic Neurotransmission
Bor Luen Tang · 2019 · Cells
Recent advances in using Drosophila to model neurodegenerative diseases
Bingwei Lu · 2009 · APOPTOSIS
Neuronal Cx3cr1 Deficiency Protects against Amyloid β-Induced Neurotoxicity
Dworzak, Jenny, Renvoisé, Benoît, Habchi, Johnny, Yates, Emma V., Combadière, Christophe, Knowles, Tuomas P., Dobson, Christopher M., Blackstone, Craig, Paulsen, Ole, Murphy, Philip M. · 2015 · PLOS ONE
Neuroprotective Effect of 2-Aminoethoxydiphenyl Borate (2-APB) in Amyloid β-Induced Memory Dysfunction: A Mechanistic Study
Pavan Thapak, Pragyanshu Khare, Mahendra Bishnoi, Shyam Sunder Sharma · 2020 · Cellular and Molecular Neurobiology
Plasminogen Activators in Neurovascular and Neurodegenerative Disorders
Manuel Yepes, Yena Woo, Cynthia Martín-Jiménez · 2021 · International Journal of Molecular Sciences
Specific Disruption of Hippocampal Mossy Fiber Synapses in a Mouse Model of Familial Alzheimer's Disease
Scott A. Wilke, Tara Raam, Joseph K. Antonios, Eric A. Bushong, Edward H. Koo, Mark H. Ellisman, Anirvan Ghosh · 2014 · PLoS ONE
APP depletion alters selective pre- and post-synaptic proteins
Martinsson, Isak, Capetillo-Zarate, Estibaliz, Faideau, Mathilde, Willén, Katarina, Esteras, Noemi, Frykman, Susanne, Tjernberg, Lars O., Gouras, Gunnar K. · 2019 · Molecular and Cellular Neuroscience
Endophilin2 Interacts with GluA1 to Mediate AMPA Receptor Endocytosis Induced by Oligomeric Amyloid-β
Jifeng Zhang, Yichen Yin, Zhisheng Ji, Zhenbin Cai, Bo Zhao, Jiong Li, Minghui Tan, Guoqing Guo · 2017 · Neural Plasticity
β-Amyloid Inhibits E-S Potentiation through Suppression of Cannabinoid Receptor 1-Dependent Synaptic Disinhibition
Adrienne Orr, Jesse E. Hanson, Dong Li, Adam Klotz, Sarah Wright, Dale Schenk, Peter A. Seubert, Daniel V. Madison · 2014 · Neuron
Striatal-Enriched Protein Tyrosine Phosphatase in Alzheimer’s Disease
Jian Xu, Pradeep K. Kurup, Angus Clark Nairn, Paul J. Lombroso · 2012 · Advances in pharmacology
Geniposide Alleviates Amyloid-Induced Synaptic Injury by Protecting Axonal Mitochondrial Trafficking
Haijing Zhang, Chunhui Zhao, Cui Lv, Xiaoli Liu, Shijing Du, Zhi Li, Yongyan Wang, Wensheng Zhang · 2017 · Frontiers in Cellular Neuroscience
Urokinase-Type Plasminogen Activator Protects Cerebral Cortical Neurons from Soluble Aβ-Induced Synaptic Damage
Ariel Díaz, Paola Merino, Jidong Guo, Manuel Yepes, Patrick McCann, Tapasya Katta, Elise M. Tong, Enrique R. Torre, Srikant Rangaraju, Manuel Yepes · 2020 · Journal of Neuroscience
p85S6K sustains synaptic GluA1 to ameliorate cognitive deficits in Alzheimer’s disease
Jia‐Bing Li, Xiaoyu Hu, Mu-Wen Chen, Cai‐Hong Xiong, Na Zhao, Yan‐Hui Ge, Hao Wang, Xiaoling Gao, Nan‐Jie Xu, Lan‐Xue Zhao et al. · 2023 · Translational Neurodegeneration
Heterogeneous Association of Alzheimer’s Disease-Linked Amyloid-β and Amyloid-β Protein Precursor with Synapses
Katarina Ingrid Willén, Agnieszka Sroka-Oleksiak, Reisuke H. Takahashi, Gunnar K. Gouras · 2017 · Journal of Alzheimer s Disease
Effects of Platelet-Rich Plasma on Cellular Populations of the Central Nervous System: The Influence of Donor Age
Diego Delgado, Ane Miren Bilbao, Maider Beitia, Ane Garate, Pello Sánchez, Imanol González‐Burguera, Amaia Isasti, Maider López de Jesús, Jone Zuazo-Ibarra, Alejandro Montilla et al. · 2021 · International Journal of Molecular Sciences
Distinctive roles of different β‐amyloid 42 aggregates in modulation of synaptic functions
Hsueh‐Cheng Chiang, Koichi Iijima, Inessa Hakker, Yi Zhong · 2009 · The FASEB Journal
Inhibition of the Motor Protein Eg5/Kinesin-5 in Amyloid β-Mediated Impairment of Hippocampal Long-Term Potentiation and Dendritic Spine Loss
Ronald K. Freund, Emily S. Gibson, Huntington Potter, Mark L. Dell’Acqua · 2016 · Molecular Pharmacology
Mitochondria-Targeted Molecules as Potential Drugs to Treat Patients With Alzheimer's Disease
Arubala P. Reddy, P. Hemachandra Reddy · 2017 · Progress in molecular biology and translational science
β-amyloid and glutamate receptors
Laura Gasparini, Alexander E. Dityatev · 2008 · Experimental Neurology
Aberrant Co-localization of Synaptic Proteins Promoted by Alzheimer’s Disease Amyloid-β Peptides: Protective Effect of Human Serum Albumin
Marta Domínguez-Prieto, Ana Luisa Velasco, Lourdes Vega, Arantxa Tabernero, José M. Medina · 2016 · Journal of Alzheimer s Disease
Behavioral alterations are associated with vitamin B12 deficiency in the transcobalamin receptor/CD320 KO mouse
Kaveri Arora, Jeffrey M. Sequeira, Alejandro Ivan Hernandez, Juan Marcos Alarcón, Edward V. Quadros · 2017 · PLoS ONE
Bryostatin-1 vs. TPPB: Dose-Dependent APP Processing and PKC-α, -δ, and -ε Isoform Activation in SH-SY5Y Neuronal Cells
P. Yi, Lisa M. Schrott, Trevor P. Castor, John Alexander · 2012 · Journal of Molecular Neuroscience
Understanding the Role of the BAI Subfamily of Adhesion G Protein-Coupled Receptors (GPCRs) in Pathological and Physiological Conditions
Sun Young Moon, Seong-Ah Shin, Yong‐Seok Oh, Hyun Ho Park, Chang Sup Lee · 2018 · Genes
Alteration in synaptic nanoscale organization dictates amyloidogenic processing in Alzheimer's disease
Shekhar Kedia, Pratyush Ramakrishna, Pallavi Rao Netrakanti, Nivedita Singh, Sangram S. Sisodia, Mini Jose, Sathish Kumar, Anita Mahadevan, Narendrakumar Ramanan, Suhita Nadkarni et al. · 2020 · iScience
Novel approaches to increase synaptic resilience as potential treatments for Alzheimer’s disease
Pham, Andrew Q., Dore, Kim · 2023 · Seminars in Cell & Developmental Biology
Caspase-1/IL-1β represses membrane transport of GluA1 by inhibiting the interaction between Stargazin and GluA1 in Alzheimer’s disease
Xunhu Gu, Han‐Jun Wu, Yuqin Xie, Lijun Xu, Xu Liu, Wei Wang · 2021 · Molecular Medicine
Alzheimer’s Disease beyond Calcium Dysregulation: The Complex Interplay between Calmodulin, Calmodulin-Binding Proteins and Amyloid Beta from Disease Onset through Progression
Danton H. O’Day · 2023 · Current Issues in Molecular Biology
Relationships Between Expression of Apolipoprotein E and β-Amyloid Precursor Protein Are Altered in Proximity to Alzheimer β-Amyloid Plaques
Steven W. Barger, K. Mark DeWall, Ling Liu, Robert Emil Mrak, W. Sue T. Griffin · 2008 · Journal of Neuropathology & Experimental Neurology
Lysosomal Dysfunction Produces Distinct Alterations in Synaptic α-Amino-3-Hydroxy-5-Methylisoxazolepropionic Acid and N-Methyl-D-Aspartate Receptor Currents in Hippocampus
Patrick M. Kanju, Kodeeswaran Parameshwaran, Thirumalini Vaithianathan, Catrina Sims‐Robinson, Kevin W. Huggins, Jennifer Bendiske, Sophia Ryzhikov, Ben A. Bahr, Vishnu D. Suppiramaniam · 2007 · Journal of Neuropathology & Experimental Neurology
RETRACTED: Detection of Peri-Synaptic Amyloid-β Pyroglutamate Aggregates in Early Stages of Alzheimer's Disease and in AβPP Transgenic Mice Using a Novel Monoclonal Antibody
Markus Mandler, Edward M. Rockenstein, Kiren K. Ubhi, Lawrence A. Hansen, Anthony Adame, Sarah A. Michael, Douglas R Galasko, Radmila Santic, Frank Mattner, Eliezer Masliah · 2012 · Journal of Alzheimer s Disease · Retracted
Submicromolar Aβ42 reduces hippocampal glutamate receptors and presynaptic markers in an aggregation-dependent manner
Meagan L. Wisniewski, Jeannie Hwang, Ben A. Bahr · 2011 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Modulation of the MAPKs pathways affects Aβ-induced cognitive deficits in Alzheimer’s disease via activation of α7nAChR
Ke-Wei Chang, Hang-Fan Zong, Mohammad Yasir Rizvi, Kaige Ma, Wanying Zhai, Meng Wang, Weina Yang, Shengfeng Ji, Yi‐Hua Qian · 2020 · Neurobiology of Learning and Memory
Developing a complete pharmacology for AMPA receptors: A perspective on subtype-selective ligands
James J. Fleming, Pamela M. England · 2010 · Bioorganic & Medicinal Chemistry
BACE1 Is Necessary for Experience-Dependent Homeostatic Synaptic Plasticity in Visual Cortex
Petrus, Emily, Lee, Hey-Kyoung · 2014 · Neural Plasticity
AMPA receptors in Alzheimer disease: Pathological changes and potential therapeutic targets
Luying Ning, Rongjing Shen, Bingqing Xie, Yong Jiang, Xiaoqi Geng, Wei Dong · 2024 · Journal of Neuropathology & Experimental Neurology
Alzheimer’s Disease Pathology and Assistive Nanotheranostic Approaches for Its Therapeutic Interventions
Anuvab Dey, Subhrojyoti Ghosh, Ramya Lakshmi Rajendran, Tiyasa Bhuniya, Purbasha Das, Bidyabati Bhattacharjee, Sagnik Das, Atharva Anand Mahajan, Anushka Samant, Krishnan Anand et al. · 2024 · International Journal of Molecular Sciences
Acetylation of AMPA Receptors Regulates Receptor Trafficking and Rescues Memory Deficits in Alzheimer's Disease
Margaret G. O’Connor, Yangping Shentu, Guan Wang, Wenting Hu, Zhendong Xu, Xiaochuan Wang, Rong Liu, Heng‐Ye Man · 2020 · iScience
Overexpression of LIMK1 in hippocampal excitatory neurons improves synaptic plasticity and social recognition memory in APP/PS1 mice
Haiwang Zhang, Youssif Ben Zablah, An Liu, Dongju Lee, Haorui Zhang, Yanghong Meng, Changxi Zhou, Xingde Liu, Yiming Wang, Zhengping Jia · 2021 · Molecular Brain
Hyperoside improves learning and memory deficits by amyloid β1-42 in mice through regulating synaptic calcium-permeable AMPA receptors
Jee Hyun Yi, Somin Moon, Eunbi Cho, Huiyoung Kwon, Seungjin Lee, Jieun Jeon, A Young Park, Ye Hee Lee, Kyoung Ja Kwon, Jong Hoon Ryu et al. · 2022 · European Journal of Pharmacology
Alzheimer’s Disease Is Responsible for Progressive Age-Dependent Differential Expression of Various Protein Cascades in Retina of Mice
Javed Iqbal, Kaoyuan Zhang, Na Jin, Yuxi Zhao, Xukun Liu, Qiong Liu, Jiazuan Ni, Liming Shen · 2019 · ACS Chemical Neuroscience
Synaptic Protein 1-Takusan Mitigates Amyloid- -Induced Synaptic Loss via Interaction with Tau and Postsynaptic Density-95 at Postsynaptic Sites
N. Nakanishi, Scott D. Ryan, X. Zhang, Asmat Ullah Khan, T. Holland, E.-G. Cho, Xiumei Huang, Francesca‐Fang Liao, Hui Xu, Stuart A. Lipton et al. · 2013 · Journal of Neuroscience
Reciprocal regulation of cholesterol and beta amyloid at the subcellular level in Alzheimer’s disease
E Chaves · 2012 · Canadian Journal of Physiology and Pharmacology
c-Abl Deficiency Provides Synaptic Resiliency Against Aβ-Oligomers
Daniela A. Gutiérrez, Lina M. Vargas, América Chandía-Cristi, Catalina de la Fuente, Nancy R. Leal, Alejandra R. Alvarez · 2019 · Frontiers in Cellular Neuroscience
Altered distribution of mGlu2 receptors in β-amyloid-affected brain regions of Alzheimer cases and aged PS2APP mice
Grayson J. Richards, Jürg Messer, Richard L. M. Faull, Heinz Stadler, Jürgen Wichmann, Philipp N. Huguenin, Bernd Bohrmann, Vincent Mutel · 2010 · Brain Research
Postsynaptic GluR2 Involved in Amelioration of Aβ-Induced Memory Dysfunction by KAIXIN-San Through Rescuing Hippocampal LTP in Mice
Bo Zhang, Yan Li, Jiawei Liu, Xuewei Liu, Wei Wen, Yu Gui Cui, Shu-Ming Huang · 2018 · Rejuvenation Research
Neurotrophic activity of jiadifenolide on neuronal precursor cells derived from human induced pluripotent stem cells
Masaki Shoji, Megumi Nishioka, Hiroki Minato, Kenichi Harada, Miwa Kubo, Yoshiyasu Fukuyama, Takashi Kuzuhara · 2016 · Biochemical and Biophysical Research Communications
Memorcise and Alzheimer’s disease
Paul Dinneen Loprinzi, Emily Frith, Pamela Ponce · 2018 · The Physician and Sportsmedicine
Calcitonin native prefibrillar oligomers but not monomers induce membrane damage that triggers NMDA-mediated Ca2+-influx, LTP impairment and neurotoxicity
Marcello Belfiore, Ida Cariati, Andrea Matteucci, Lucia Gaddini, Gianfranco Macchia, Raoul Fioravanti, Claudio Frank, Virginia Tancredi, Giovanna D’Arcangelo, Marco Diociaiuti · 2019 · Scientific Reports
Kalirin‐7 prevents dendritic spine dysgenesis induced by amyloid beta‐derived oligomers
Zhong Xie, Lauren P. Shapiro, Michael E. Cahill, Theron A. Russell, Pascale N. Lacor, William L. Klein, Peter Penzes · 2018 · European Journal of Neuroscience
Prolonged Volatile Anesthetic Exposure Exacerbates Cognitive Impairment and Neuropathology in the 5xFAD Mouse Model of Alzheimer’s Disease
Fanglei Han, Jia Zhao, Guoqing Zhao · 2021 · Journal of Alzheimer s Disease
Synthetic, Cell-Derived, Brain-Derived, and Recombinant β-Amyloid: Modelling Alzheimer’s Disease for Research and Drug Development
Kseniya B. Varshavskaya, Vladimir A. Mitkevich, Alexander А. Makarov, Evgeny P. Barykin · 2022 · International Journal of Molecular Sciences
Impairments in endogenous AMPA receptor dynamics correlates with learning deficits in Alzheimer’s disease model mice
Kongjie Lu, Chenyang Li, Jiao Liu, Jinpeng Wang, Yongfeng Li, Bin He, Junzhao Li, Xiaochen Zhang, Mengping Wei, Yonglu Tian et al. · 2023 · Proceedings of the National Academy of Sciences
Distinct and dementia‐related synaptopathy in the hippocampus after military blast exposures
Michael Fernandes de Almeida, Thuvan N. Piehler, Kelly E. Carstens, Meilan Zhao, Mahsa Samadi, Serena M. Dudek, Christopher J. Norton, Catherine M. Parisian, Karen L. G. Farizatto, Ben A. Bahr · 2021 · Brain Pathology
The Na+/Ca2+ Exchanger 3 Is Functionally Coupled With the NaV1.6 Voltage-Gated Channel and Promotes an Endoplasmic Reticulum Ca2+ Refilling in a Transgenic Model of Alzheimer’s Disease
Ilaria Piccialli, Roselia Ciccone, Agnese Secondo, Francesca Boscia, Valentina Tedeschi, Valéria de Rosa, Pasquale Cepparulo, Lucio Annunziato, Anna Pannaccione · 2021 · Frontiers in Pharmacology
Review: The fate of cell grafts for the treatment of H untington's disease: the post‐mortem evidence
Giulia Cisbani, Francesca Cicchetti · 2013 · Neuropathology and Applied Neurobiology
Treadmill Exercise Facilitates Synaptic Plasticity in APP/PS1 Mice by Regulating Hippocampal AMPAR Activity
Laikang Yu, Yan Li, Yuanyuan Lv, Boya Gu, Jiajia Cai, Qing-song Liu, Li Ru Zhao · 2024 · Cells
Amyloid-β (1-42) peptide induces rapid NMDA receptor-dependent alterations at glutamatergic synapses in the entorhinal cortex
Olayemi Joseph Olajide, Clifton Andrew Chapman · 2021 · Neurobiology of Aging
Region-specific changes in the microanatomy of single dendritic spines over time might account for selective memory alterations in ageing hAPPsweTg2576 mice, a mouse model for Alzheimer disease
Silvia Middei, Leonardo Restivo, Antonio Caprioli, Massimiliano Aceti, Martine Ammassari‐Teule · 2008 · Neurobiology of Learning and Memory
Activation of innate immune receptor TLR9 by mitochondrial DNA plays essential roles in the chemical long-term depression of hippocampal neurons
Naoya Atarashi, Misaki Morishita, Shinji Matsuda · 2024 · Journal of Biological Chemistry
Genetic Inactivation of Free Fatty Acid Receptor 3 Impedes Behavioral Deficits and Pathological Hallmarks in the APPswe Alzheimer’s Disease Mouse Model
Marta Zamarbide, Eva Martínez‐Pinilla, Francisco Javier Gil-Bea, Masashi Yanagisawa, Rafael Franco, Alberto Pérez‐Mediavilla · 2022 · International Journal of Molecular Sciences
The Role of Mesenchymal Stem Cells in Regulating Astrocytes-Related Synapse Dysfunction in Early Alzheimer’s Disease
Cong Liu · 2022 · Frontiers in Neuroscience
Reelin and APP Cooperatively Modulate Dendritic Spine Formation In Vitro and In Vivo
Hyunju Lee, Jin-Hee Park, Justin H. Trotter, James N. Maher, Kathleen E. Keenoy, You Mi Jang, Youngeun Lee, Jae‐Ick Kim, Edwin J. Weeber, Hyang‐Sook Hoe · 2023 · Experimental Neurobiology
Astrocytic Hevin/ SPARCL ‐1 Regulates Cognitive Decline in Pathological and Normal Brain Aging
Felipe Cabral‐Miranda, Ana Paula Bérgamo Araújo, Danilo B. Medinas, Flávia Carvalho Alcântara Gomes · 2025 · Aging Cell
Subtle genomic DNA damage induces intraneuronal production of amyloid‐β (1‐42) by increasing β‐secretase activity
Hrishita Das, Sukanya Sarkar, Ramesh Kumar Paidi, Subhas Chandra Biswas · 2021 · The FASEB Journal
Unraveling the mystery of citrate transporters in Alzheimer’s disease: An updated review
Anirban Goutam Mukherjee, Shatakshi Mishra, Abilash Valsala Gopalakrishnan, Sandra Kannampuzha, Reshma Murali, Uddesh Ramesh Wanjari, Bala Kumar Stany, Balachandar Vellingiri, Harishkumar Madhyastha, Kanagavel Deepankumar et al. · 2025 · Ageing Research Reviews
Early-Occurring Dendritic Spines Alterations in Mouse Models of Alzheimer’s Disease Inform on Primary Causes of Neurodegeneration
Martine Ammassari‐Teule · 2020 · Frontiers in Synaptic Neuroscience
The Alzheimer's Disease Risk Gene CD2AP Functions in Dendritic Spines by Remodeling F-Actin
Farzaneh Sadat Mirfakhar, Jorge Castanheira, Raquel Domingues, Jose Silva Ramalho, Cláudia Guimas Almeida · 2024 · Journal of Neuroscience
Genetic ablation of neuronal mitochondrial calcium uptake impedes Alzheimer’s disease progression
Pooja Jadiya, E.V. Berezhnaya, Devin W. Kolmetzky, Dhanendra Tomar, Henry M. Cohen, Shatakshi Shukla, Manfred Thomas, Salman Khaledi, Joanne F. Garbincius, Liam Kennedy et al. · 2026 · The EMBO Journal
Modeling Presenilin-Dependent Familial Alzheimer's Disease: Emphasis on Presenilin Substrate-Mediated Signaling and Synaptic Function
Angèle Parent, Gopal Thinakaran · 2010 · International Journal of Alzheimer s Disease
Resilience to structural and molecular changes in excitatory synapses in the hippocampus contributes to cognitive function recovery in Tg2576 mice
Carolina Aguado, Sara Badesso, José Martínez Hernández, Alejandro Martín‐Belmonte, Rocío Alfaro‐Ruiz, Miriam Fernández, Ana Esther Moreno‐Martínez, Mar Cuadrado‐Tejedor, Ana García‐Osta, Rafael Luján · 2023 · Neural Regeneration Research
Alzheimer’s genetic risk factor Bin1 controls synapse vesicle exo-endocytosis in inhibitory synapses
Mariana Afonso Barata, Catarina Perdigão, Jose Silva Ramalho, Edgar R. Gomes, Cláudia Guimas Almeida · 2025 · Cell Reports
Neuronal deletion of nSMase2 reduces the production of Aβ and directly protects neurons
Şehmus Tohumeken, Pragney Deme, Seung Wan Yoo, Sujasha Gupta, Rana Rais, Barbara Stauch Slusher, Norman J. Haughey · 2023 · Neurobiology of Disease