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Cited by 364Alzheimer's disease research and treatmentsRedox biology and oxidative stressDementia and Cognitive Impairment Research

Identification of nitrated proteins in Alzheimer’s disease brain using a redox proteomics approach

Sultana, Rukhsana, Poon, H. Fai, Cai, Jian, Pierce, William M., Merchant, Michael, Klein, Jon B., Markesbery, William R., Butterfield, D. Allan·2006·Neurobiology of Disease
DOI 10.1016/j.nbd.2005.10.004
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Abstract

Nitric oxide (NO) has been implicated in the pathophysiology of a number of neurodegenerative diseases including Alzheimer's disease (AD). In the present study, using a proteomics approach, we identified enolase, glyceraldehyde-3-phosphate dehydrogenase, ATP synthase alpha chain, carbonic anhydrase-II, and voltage-dependent anion channel-protein as the targets of nitration in AD hippocampus, a region that shows a extensive deposition of amyloid beta-peptide, compared with the age-matched control brains. Immunoprecipitation and Western blotting techniques were used to validate the correct identification of these proteins. Our results are discussed in context of the role of oxidative stress as one of the important mechanisms of neurodegeneration in AD.

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References 94 · Cited by 364

Authors
Sultana, R., Poon, H. F., Cai, J., Pierce, W. M., Merchant, M., Klein, J. B., Markesbery, W. R., & Butterfield, D. A.
Affiliations
  • University of Kentucky (US)
  • University of Louisville (US)
Corresponding author
Butterfield, D. Allan
ORCID
Venue
Neurobiology of Disease
Publisher
Elsevier BV
Published
2006-04
Volume
22
Issue
1
Pages
76-87
ISSN
0969-9961 (ISSN-L)
DOI
10.1016/j.nbd.2005.10.004
OpenAlex
W2067195259
Cited by
364
References
94
Citations by year
2026: 7 · 2025: 7 · 2024: 14 · 2023: 11 · 2022: 10 · 2021: 14 · 2020: 14 · 2019: 7 · 2018: 11 · 2017: 12 · 2016: 14 · 2015: 18 · 2014: 21 · 2013: 20 · 2012: 25
FWCI
13.18
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neurobiology of Disease (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • University of Kentucky
  • National Institutes of Health
  • National Institute on Aging (5P01-AG05119, P01AG010836, P01AG005119, AG 10836, AG0 5119)
  • National Heart, Lung, and Blood Institute (HL-66358, R01HL066358)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
Alzheimer's disease, nitration, nitric oxide, redox proteomics, oxidative stress, hippocampus, enolase, glyceraldehyde-3-phosphate dehydrogenase, carbonic anhydrase II, voltage-dependent anion channel, amyloid-beta, neurodegeneration
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Female, Hippocampus, Humans, Male, Nerve Degeneration, Nerve Tissue Proteins, Nitrates, Oxidation-Reduction, Phosphopyruvate Hydratase, Phosphorylation, Tyrosine, Oxidative Stress, Carbonic Anhydrase II, Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+), ATP Synthetase Complexes, Proteomics, Voltage-Dependent Anion Channel 1

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