Osteopontin is extensively expressed by macrophages following CNS demyelination but has a redundant role in remyelination

Zhao, Chao; Fancy, Stephen P.J.; ffrench-Constant, Charles; Franklin, Robin J.M.

doi:10.1016/j.nbd.2008.04.007

Osteopontin is extensively expressed by macrophages following CNS demyelination but has a redundant role in remyelination

Osteopontin (OPN) is a key immunoregulator in the autoimmune-mediated demyelinating disease multiple sclerosis. OPN may also play a role in the remyelination since it is 1) a ligand for alpha V integrins, several of which regulate the properties of the oligodendrocyte precursor cells (OPCs) prima…