Aggrecan expression, a component of the inhibitory interneuron perineuronal net, is altered following an early-life seizure
Open accessAbstract
The perineuronal net (PN), a component of the neural extracellular matrix (ECM), is a dynamic structure whose expression decreases following diminished physiological activity. Here, we analyzed the effects of increased neuronal activity on the development of aggrecan, a component of the PN, in the hippocampus. We show aggrecan expression to be prominent around parvalbumin (PV) interneurons in the postnatal hippocampus. Moreover, after seizure induction in early life there was a significant increase in aggrecan expression in a region specific manner during the course of development. We conclude that increased neuronal activity leads to accelerated expression of PNs in the hippocampus that attenuates in the adult hippocampus. This study shows the dynamic nature of the PN component of the ECM and the role neuronal activity has in molding the extracellular milieu of inhibitory interneurons.
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Aggrecan expression and glycosylation state are activity-dependent.
“In addition, both aggrecan expression (McRae et al, 2010) and glycosylation state (Lander et al, 1997) are activity-dependent.”
From Reduced Labeling of Parvalbumin Neurons and Perineuronal Nets in the Dorsolateral Prefrontal Cortex of Subjects with Schizophrenia (2016) · cites this paper as McRae et al, 2010
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References 53 · Cited by 49
- Authors
- McRae, P. A., Baranov, E., Sarode, S., Brooks-Kayal, A. R., & Porter, B. E.
- Affiliations
- Children's Hospital of Philadelphia (US)
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 39
- Issue
- 3
- Pages
- 439-448
- ISSN
- 0969-9961 (ISSN-L)
- PMC
- PMC2935142
- OpenAlex
- W2067716913
- Cited by
- 49
- References
- 53
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 4 · 2018: 10 · 2017: 4 · 2016: 4 · 2015: 3 · 2014: 2 · 2013: 1 · 2012: 4
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neurobiology of Disease (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS056222)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Keywords
- aggrecan, perineuronal nets, parvalbumin interneurons, inhibitory interneurons, early-life seizures, hippocampus, extracellular matrix, neuronal activity, postnatal development, excitotoxicity
- MeSH terms
- Analysis of Variance, Animals, Cell Count, Hippocampus, Immunohistochemistry, Interneurons, Kainic Acid, Male, Parvalbumins, Seizures, Rats, Sprague-Dawley, Reverse Transcriptase Polymerase Chain Reaction, Rats, Aggrecans
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