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Cited by 175Mitochondrial Function and PathologyAlzheimer's disease research and treatmentsAutophagy in Disease and Therapy

Role of mitochondrial homeostasis and dynamics in Alzheimer's disease

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Selfridge, J. Eva, E, Lezi, Lu, Jianghua, Swerdlow, Russell H.·2013·Neurobiology of Disease
DOI 10.1016/j.nbd.2011.12.057PMC PMC3337963
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Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disease that affects a staggering percentage of the aging population and causes memory loss and cognitive decline. Mitochondrial abnormalities can be observed systemically and in brains of patients suffering from AD, and may account for part of the disease phenotype. In this review, we summarize some of the key findings that indicate mitochondrial dysfunction is present in AD-affected subjects, including cytochrome oxidase deficiency, endophenotype data, and altered mitochondrial morphology. Special attention is given to recently described perturbations in mitochondrial autophagy, fission-fusion dynamics, and biogenesis. We also briefly discuss how mitochondrial dysfunction may influence amyloidosis in Alzheimer's disease, why mitochondria are a valid therapeutic target, and strategies for addressing AD-specific mitochondrial dysfunction.

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Authors
Selfridge, J. E., E, L., Lu, J., & Swerdlow, R. H.
Affiliations
University of Kansas (US)
Corresponding author
Swerdlow, Russell H.
ORCID
Venue
Neurobiology of Disease
Publisher
Elsevier BV
Published
2013-03
Volume
51
Pages
3-12
ISSN
0969-9961 (ISSN-L)
DOI
10.1016/j.nbd.2011.12.057
PMC
PMC3337963
OpenAlex
W2072595318
Cited by
175
References
204
Citations by year
2026: 4 · 2025: 10 · 2024: 15 · 2023: 19 · 2022: 14 · 2021: 12 · 2020: 19 · 2019: 9 · 2018: 11 · 2017: 12 · 2016: 12 · 2015: 11 · 2014: 15 · 2013: 9 · 2012: 3
FWCI
1.12
Type
journal article
Language
en
Open access
Licence
Locations
  • Neurobiology of Disease (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Institute on Aging (P30AG035982)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords
Alzheimer's disease, mitochondrial dysfunction, mitochondrial homeostasis, mitochondrial dynamics, mitochondrial fission and fusion, mitophagy, mitochondrial biogenesis, cytochrome oxidase deficiency, endophenotypes, mitochondrial morphology, amyloidosis, therapeutic target
MeSH terms
Alzheimer Disease, Animals, Homeostasis, Humans, Mitochondria, Mitochondrial Dynamics

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