Chronic stress-induced gut dysfunction exacerbates Parkinson's disease phenotype and pathology in a rotenone-induced mouse model of Parkinson's disease

Dodiya, Hemraj B.; Forsyth, Christopher B.; Voigt, Robin M.; Engen, Phillip A.; Patel, Jinal; Shaikh, Maliha; Green, Stefan J.; Naqib, Ankur; Roy, Avik; Kordower, Jeffrey H.; Pahan, Kalipada; Shannon, Kathleen M.; Keshavarzian, Ali

doi:10.1016/j.nbd.2018.12.012

Chronic stress-induced gut dysfunction exacerbates Parkinson's disease phenotype and pathology in a rotenone-induced mouse model of Parkinson's disease

Recent evidence provides support for involvement of the microbiota-gut-brain axis in Parkinson's disease (PD) pathogenesis. We propose that a pro-inflammatory intestinal milieu, due to intestinal hyper-permeability and/or microbial dysbiosis, initiates or exacerbates PD pathogenesis. One factor t…