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Cited by 160Schizophrenia research and treatmentNeurotransmitter Receptor Influence on BehaviorParkinson's Disease Mechanisms and Treatments

Dopamine and psychosis: Theory, pathomechanisms and intermediate phenotypes

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Tost, Heike, Alam, Tajvar, Meyer-Lindenberg, Andreas·2010·Neuroscience & Biobehavioral Reviews
DOI 10.1016/j.neubiorev.2009.06.005PMC PMC2838993
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Abstract

Schizophrenia is a chronic, severe, and disabling brain disorder arising from the adverse interaction of predisposing risk genes and environmental factors. The psychopathology is characterized by a wide array of disturbing cognitive, emotional, and behavioral symptoms that interfere with the individual's capacity to function in society. Contemporary pathophysiological models assume that psychotic symptoms are triggered by a dysregulation of dopaminergic activity in the brain, a theory that is tightly linked to the serendipitous discovery of the first effective antipsychotic agents in the early 1950s. In recent years, the availability of modern neuroimaging techniques has significantly expanded our understanding of the key mediator circuits that bridge the gap between genetic susceptibility and clinical phenotype. This paper discusses the pathophysiological concepts, molecular mechanisms and neuroimaging evidence that link psychosis to disturbances in dopamine neurotransmission.

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Authors
Tost, H., Alam, T., & Meyer-Lindenberg, A.
Affiliations
United States Department of Health and Human Services (US)
ORCID
Tost, Heike
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
2010-04
Volume
34
Issue
5
Pages
689-700
ISSN
0149-7634 (ISSN-L)
DOI
10.1016/j.neubiorev.2009.06.005
PMC
PMC2838993
OpenAlex
W1985987483
Cited by
160
References
134
Citations by year
2026: 4 · 2025: 14 · 2024: 9 · 2023: 13 · 2022: 14 · 2021: 12 · 2020: 11 · 2019: 13 · 2018: 6 · 2017: 9 · 2016: 8 · 2015: 11 · 2014: 8 · 2013: 8 · 2012: 10
FWCI
0.84
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (Z99 MH999999)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords
dopamine, psychosis, schizophrenia, dopaminergic dysfunction, endophenotypes, antipsychotic drugs, neuroimaging, genetic susceptibility, pathophysiology, neurotransmission
MeSH terms
Animals, Mental Disorders, Brain, Dopamine, Humans, Models, Neurological, Phenotype

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