Region and state specific glutamate downregulation in major depressive disorder: a meta-analysis of 1H-MRS findings.

Luykx, J.J.; Laban, K.G.; van den Heuvel, M.P.; Boks, M.P.M.; Mandl, R.C.W.; Kahn, R.S.; Bakker, S.C.

doi:10.1016/j.neubiorev.2011.05.014

Region and state specific glutamate downregulation in major depressive disorder: a meta-analysis of 1H-MRS findings.

For major depressive disorder (MDD), magnetic resonance spectroscopy ((1)H-MRS) studies of glutamate, glutamine and Glx (the composite measure of mainly glutamate and glutamine) have yielded inconclusive or seemingly inconsistent results. We therefore systematically reviewed whether in vivo conce…