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Cited by 339Stress Responses and CortisolMemory and Neural MechanismsNeurotransmitter Receptor Influence on Behavior

Chronic stress and brain plasticity: Mechanisms underlying adaptive and maladaptive changes and implications for stress-related CNS disorders

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Radley, Jason, Morilak, David, Viau, Victor, Campeau, Serge·2015·Neuroscience & Biobehavioral Reviews
DOI 10.1016/j.neubiorev.2015.06.018PMC PMC4684432
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Abstract

Stress responses entail neuroendocrine, autonomic, and behavioral changes to promote effective coping with real or perceived threats to one's safety. While these responses are critical for the survival of the individual, adverse effects of repeated exposure to stress are widely known to have deleterious effects on health. Thus, a considerable effort in the search for treatments to stress-related CNS disorders necessitates unraveling the brain mechanisms responsible for adaptation under acute conditions and their perturbations following chronic stress exposure. This paper is based upon a symposium from the 2014 International Behavioral Neuroscience Meeting, summarizing some recent advances in understanding the effects of stress on adaptive and maladaptive responses subserved by limbic forebrain networks. An important theme highlighted in this review is that the same networks mediating neuroendocrine, autonomic, and behavioral processes during adaptive coping also comprise targets of the effects of repeated stress exposure in the development of maladaptive states. Where possible, reference is made to the similarity of neurobiological substrates and effects observed following repeated exposure to stress in laboratory animals and the clinical features of stress-related disorders in humans.

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  • Chronic stress exposure during early childhood and adolescence is associated with structural and functional changes in the amygdala and hippocampus, increasing risk for altered acute stress responses.

    “chronic exposure to stress, particularly during early childhood and adolescent development, is associated with structural and functional changes in both the amygdala and hippocampus, thus increasing the risk for altered acute stress responses (Radley et al. 2015)”

    From Adolescent Suicide as a Failure of Acute Stress-Response Systems. (2019) · cites this paper as Radley et al. 2015

    The Amygdala and Hippocampal Formation sections describe structural and functional changes with repeated or chronic stress, and the Amygdala section describes sensitized stress-response systems. The review also says early-life experience influences stress responsiveness, but the cited passages do not establish the claimed sequence specifically for chronic exposure during early childhood and adolescence. Page numbers are unavailable in our copy. (LLM, conf=0.86)

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Authors
Radley, J., Morilak, D., Viau, V., & Campeau, S.
Affiliations
  • University of Iowa (US)
  • The University of Texas at San Antonio Health Science Center (US)
  • University of British Columbia (CA)
  • University of Colorado Boulder (US)
Corresponding author
Campeau, Serge
ORCID
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
2015-11
Volume
58
Pages
79-91
ISSN
0149-7634 (ISSN-L)
DOI
10.1016/j.neubiorev.2015.06.018
PMC
PMC4684432
OpenAlex
W854901204
Cited by
339
References
339
Citations by year
2026: 28 · 2025: 40 · 2024: 25 · 2023: 77 · 2022: 22 · 2021: 36 · 2020: 22 · 2019: 31 · 2018: 14 · 2017: 20 · 2016: 20 · 2015: 4
FWCI
1.56
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Health (MH053851, MH072672, MH095972, MH077152)
  • Canadian Institutes of Health research (MOP-136856, MOP-136840)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
chronic stress, neuroplasticity, adaptive coping, maladaptive stress response, neuroendocrine stress response, autonomic stress response, stress-related disorders, repeated stress exposure
MeSH terms
Adaptation, Physiological, Animals, Brain, Humans, Stress, Physiological, Stress, Psychological

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