An overview of maternal separation effects on behavioural outcomes in mice: evidence from a four-stage methodological systematic review
Tractenberg, Saulo G., Levandowski, Mateus L., de Azeredo, Lucas Araújo, Orso, Rodrigo, Roithmann, Laura G., Hoffmann, Emerson S., Brenhouse, Heather, Grassi-Oliveira, Rodrigo·2016·Neuroscience & Biobehavioral Reviews
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- Differential effects of two early life stress paradigms on cerebellar-dependent delay eyeblink conditioningAlexandra B. Moussa‐Tooks, William P. Hetrick, John T. Green · 2020 · Neurobiology of Stress
- Relationship between infantile mother preference and neural regions activated by maternal contact in C57BL/6 miceKie Shimizu, Rieko Tanaka‐Yachi, Manami Iso, Kazuki Harada, Takashi Tsuboi, Yasuhiko Kondo, Kazuaki Nakamura · 2022 · Neuroscience Research
- Importance of the Microbiota in Early Life and Influence on Future HealthJames M. Collins, John F. Cryan, Siobhain M. O’Mahony · 2024 · Elsevier eBooks
- Maternal separation stress experienced by parents affects ovarian function in first generation of miceKajal Khodamoradi, Zahra Khosravizadeh, Hossein Amini-Khoei, Seyed Reza Hosseini, Ahmad Reza Dehpour, Gholamreza Hassanzadeh · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Maternal separation affects fronto-cortical activity in rat pups during dam-pup interactions and behavioral transitionsManon Ranger, Tatyana B. Behring, Jasmine H. Kaidbey, Muhammad Anwar, Allie B. Lipshutz, Isabelle Mollicone, Gehad Hassan, Kathryn Mayring Fasano, Nicole K. Hinz, Robert J. Ludwig et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- A Critical Role for Touch Neurons in a Skin-Brain Pathway for Stress ResilienceMelanie D. Schaffler, Micah Johnson, Benjamin Wen Qing Hing, Paul Kahler, Ian Hultman, Sanvesh Srivastava, Justin Arnold, Julie N. Blendy, Rainbo C. Hultman, Ishmail Abdus-Saboor · 2022 · SSRN Electronic Journal
- Upregulated HCN currents and reduced intrinsic excitability in prefrontal cortical pyramidal neurons after maternal separationWang, Xing, Luo, Fei, Li, Baoming · 2025 · Neurobiology of Disease
- Relationships between Mu-opioid receptors brain expression and depressive-like behaviors in animal models: A systematic reviewAndrei Sigunov, Marta Peciña, Matthew Ian Palmatier, Eric W. Sellers, Andrea D. Clements, Gerald A. Deehan · 2025 · Neuroscience & Biobehavioral Reviews
- Post-weaning maternal presence exerts a protective effect against social isolation-induced behavioural alterations in miceHiroshi Ueno, Eriko Kitano, Yu Takahashi, Sachiko Mori, Shinji Murakami, Kenta Wani, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara · 2025 · Scientific Reports
- Heterogeneous effects of maternal separation on the acoustic structure of mouse pup vocalizationsRyo Nishibori, Yuki Ito, Saori Inagaki, Motoki Akiyama, Yuta Tamai, Jun Motoyama, Kohta I. Kobayasi · 2026 · Behavioural Brain Research
- Social deprivation weakens sender–receiver coupling in mother–infant acoustic communication by altering pup vocal development in Mongolian gerbils (Meriones unguiculatus)Ryo Nishibori, Yume Kinoshita, Naoki Matsumoto, Harutaka Nakagawa, Kazuki T. Shin'ya, Yuki Ito, Yuta Tamai, Kohta I. Kobayasi · 2026 · Journal of Comparative Physiology A
- Ginseng total saponins rescue susceptibility to adult depression-like behaviors in mice induced by early-life stress via regulating CREB/BDNF/TrkB signalingYaoyao Bian, Lili Yang, Yutong Wang, Ping Lü, Wen Li, Jia Miao, Yiting Gong, Bin Zhang, Yanyun Yin · 2023 · CyTA - Journal of Food
- Maternal exercise during pregnancy: Sex-specific impacts on offspring memory and maternal deprivation effectsGuilherme Salgado Carrazoni, Pâmela Billig Mello‐Carpes · 2025 · Neuroscience Letters
- O ambiente materno influencia o desenvolvimento ponderal e a viabilidade da prole de ratos, porém não altera o cuidado maternalLoren da Silva Medeiros, P. Rodrigues, Ana Claudia Silva Sampaio, Maria Martha Bernardi · 2020 · Cadernos de Pós-Graduação em Distúrbios do Desenvolvimento
- Biometric, nutritional, biochemical, and cardiovascular outcomes in male rats submitted to an experimental model of early weaning that mimics mother abandoningRogério Barbosa de Magalhães Barros, Thaís Alvim-Silva, Júlia Raquel Nunes de Souza, Emiliana Barbosa Marques, Nazareth N. Rocha, Fernanda Brito, Christianne Brêtas Vieira Scaramello · 2020 · Journal of Developmental Origins of Health and Disease
- Family-Centered Individualized Developmental Care of the Preterm BabyOtwin Linderkamp · 2020 · Springer eBooks
- Genetic diversity shapes behavioral outcomes and reveals sex differences in mice exposed to early life stressJennifer Nguyen, Kevin Shimizu, Varvara Zlotnik, Matthew N. Nguyen, Sandra Del Toro, Michael Nguyen, Janet Ronquillo, Lindsay R. Halladay · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Long Term Effects of Early Life Maternal Separation During Tyrosine Receptor Kinase B (TrkB) KnockdownNatalie A. Prowse · 2017
- Influencia del estrés en la conducta maternal en hembras de ratónMaría Isabel Orejuela Álvarez, Maria Pilar García Pardo, Hugo Salais López, Manuela Barneo‐Muñoz, Fernando Martínez García · 2019 · Àgora de salut
- Early life stress induces age-dependent epigenetic changes in p11 gene expressionMi Kyoung Seo, Jung Goo Lee, Sung Woo Park · 2020
- Identifying the Effects of Different Juvenile Stress Protocols on Adult Fear and Anxiety-like Behaviours in C57BL/6J MiceNicole Odenwald · 2019 · TSpace (University of Toronto)
- Análise da expressão de comportamentos associados ao pânico em roedores submetidos ao modelo do ninho limitadoJefferson Manoel do Nascimento Silva · 2022
- “The wrong tools for the right job”: a critical meta-analysis of traditional tests to assess behavioural impacts of early life stressOlivia Stupart, Trevor William Robbins, Jeffrey W. Dalley · 2022 · Research Square
- Modulação da plasticidade sináptica por TREK-1 e 5HT>sub<1A>/sub< no estresse crônico pós-natal.José Francis de Oliveira · 2020 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
- Effects of environmental enrichment on the behavioural consequences of early-life stress in ratsAbeer E. Dief, Yara Ezz, Amany K. Elshorbagy, Robert M. J. Deacon, Ahmed Alrifaee, Ahmed Eltahan, chahd Wael Mansour, Ahmed Shaheen · 2023 · Bulletin of Egyptian Society for Physiological Sciences
- Childhood Separation Anxiety: Human and Preclinical StudiesMaximilian Strauss, Marco Battaglia · 2023 · Springer eBooks
- La depresión como factor de riesgo de la demencia: fisiopatología y modelos preclínicos de estudioDaniela Hernández-Enseñat, Maylin Wong-Guerra, Jeney Ramírez-Sánchez, Luis Arturo Fonseca-Fonseca, Yanier Núñez-Figueredo · 2023 · Psiquiatría Biológica
- Behavioral and inflammatory changes in rats induced by a three-hit stress model: Implications for psychiatric disordersGustavo Antunes Mastella, Isabela Hübbe de Oliveira, Amanda Kunz Godói, Leonardo Ghisi do Nascimento, Kelvin Schmoeller Alberton, Vitória Dagostim, Sarah Galatto Cancillier, Kristian Madeira, Gislaine Z. Réus, Alexandra Ioppi Zugno · 2023 · Journal of Psychiatric Research
- Effect of ketamine enantiomers and maternal deprivation on depressive-like behavior and plasma concentration of BDNF in ratsGraziele Beanes, Beatriz A. Carneiro, Gilson S. Marques, Pedro Guilherme B. de S. Nazaré, Israel N. Matos, Gilson Correia de Carvalho, Clarissa Schitine, Alex Cleber Improta Caria, Ryan dos Santos Costa, Rejane Conceição Santana · 2024 · Research Society and Development
- Start, stop, reduce, or maintain? How training and detraining during pregnancy shape maternal memory, behavior, and mother-pup interaction after maternal separationGuilherme Salgado Carrazoni, Pâmela Billig Mello‐Carpes · 2025 · Physiology & Behavior
- Modèles animaux de troubles bipolaires : vers de nouvelles perspectivesChantal Henry, Mathilde Bigot, Mariana Alonso · 2023 · Elsevier eBooks
- "Models of Depression for Preclinical Drug Discovery and Development: A Transitional Perspective"Michel Bourin · 2025 · Archives of Depression and Anxiety
- Maternal separation and post-weaning feeding behavior in rodents: A critical review and meta-analysisElin Kachuki Dory, Reut Hazani, Yoni Loterstein, Gil Zalsman, Michal Lavidor B, Aron Weller · 2025 · Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Dysfunction of the paraventricular thalamus–prelimbic cortex circuit underlies maternal separation–induced deficits in contagious painZichen Zhang, Yu Gong, Xin-Yu Su, Yujiao Deng, Rui Du, Chun-Li Li, Yan Wang, Xing-Lei Song, Qin Jiang, Ying Li et al. · 2025 · Science Advances
- Impact of brief maternal separation on rodent models of anergia induced by dopamine depletion: analysis in mice of both sexes during adulthoodMatas-Navarro, Paula, Carratalá-Ros, Carla, Martínez-Verdú, Andrea, Salamone, John D., Correa, Mercè · 2025 · Psychopharmacology
- Additional file 1 of Proteome profiling of different rat brain regions reveals the modulatory effect of prolonged maternal separation on proteins involved in cell death-related processesZdeňka Drastichová, Vladimı́r Rudajev, Pallag, Gergely, Novotny, Jiri · 2021 · Figshare
- Additional file 3 of Early-life stress elicits peripheral and brain immune activation differently in wild type and 5xFAD mice in a sex-specific mannerBachiller, S., Isabel Hidalgo, Garcia, M. G., Antonio Boza‐Serrano, Agnes Paulus, Quentin Denis, Caroline Haikal, Oscar Manouchehrian, Oxana l. Klementieva, J.-Y. Li et al. · 2022 · Figshare
- Additional file 8 of Proteome profiling of different rat brain regions reveals the modulatory effect of prolonged maternal separation on proteins involved in cell death-related processesZdeňka Drastichová, Vladimı́r Rudajev, Pallag, Gergely, Novotny, Jiri · 2021 · Figshare
- Additional file 10 of Proteome profiling of different rat brain regions reveals the modulatory effect of prolonged maternal separation on proteins involved in cell death-related processesZdeňka Drastichová, Vladimı́r Rudajev, Pallag, Gergely, Novotny, Jiri · 2021 · Figshare
- Additional file 9 of Proteome profiling of different rat brain regions reveals the modulatory effect of prolonged maternal separation on proteins involved in cell death-related processesZdeňka Drastichová, Vladimı́r Rudajev, Pallag, Gergely, Novotny, Jiri · 2021 · Figshare
- Additional file 2 of Early-life stress elicits peripheral and brain immune activation differently in wild type and 5xFAD mice in a sex-specific mannerBachiller, S., Isabel Hidalgo, Garcia, M. G., Antonio Boza‐Serrano, Agnes Paulus, Quentin Denis, Caroline Haikal, Oscar Manouchehrian, Oxana l. Klementieva, J.-Y. Li et al. · 2022 · Figshare
- Additional file 4 of Early-life stress elicits peripheral and brain immune activation differently in wild type and 5xFAD mice in a sex-specific mannerBachiller, S., Isabel Hidalgo, Garcia, M. G., Antonio Boza‐Serrano, Agnes Paulus, Quentin Denis, Caroline Haikal, Oscar Manouchehrian, Oxana l. Klementieva, J.-Y. Li et al. · 2022 · Figshare
- Additional file 3 of Proteome profiling of different rat brain regions reveals the modulatory effect of prolonged maternal separation on proteins involved in cell death-related processesZdeňka Drastichová, Vladimı́r Rudajev, Pallag, Gergely, Novotny, Jiri · 2021 · Figshare
- Additional file 1 of Early-life stress elicits peripheral and brain immune activation differently in wild type and 5xFAD mice in a sex-specific mannerBachiller, S., Isabel Hidalgo, Garcia, M. G., Antonio Boza‐Serrano, Agnes Paulus, Quentin Denis, Caroline Haikal, Oscar Manouchehrian, Oxana l. Klementieva, Li, J. Y. et al. · 2022 · Figshare
- Reversal strategies within the lateral habenula to ameliorate depressive-like behaviorsAnna Tchenio · 2017 · theses.fr (ABES)
- Role of the gut-brain axis in early stress-induced emotional vulnerabilityMarion Rincel · 2017 · theses.fr (ABES)
- Serotonin and emotional behaviours : developmental role of the 5-HT7 receptorJimmy Olusakin · 2019
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- Study of the therapeutic potentials of the induced augmentation in adult neurogenesis in a mouse model of chronic mild stress and depressionHoda Eliwa · 2020 · theses.fr (ABES)
- Rôle de la neurogenèse hippocampique adulte dans la résilience au stress : étude dans deux modèles murins de stress aigu et chroniqueBarbara Planchez · 2021 · theses.fr (ABES)
- Early-life adversity in rodents: Experimental design is of the essenceRixt van der Veen, Marian Joëls, Anikó Kőrösi · 2026 · Neurobiology of Stress
- Transgenerational Programming of Brain Development and Behaviour in Response to Early-Life AdversityJörg Bock · 2026 · Springer eBooks
- Combined maternal separation and limited bedding-nesting increase goal tracking, delay discounting, and impulsive action, and moderate sign-tracking-perseverance associations in male ratsJulián Cifuentes, Mónica Arias-Higuera, Cesar Acevedo-Triana, Michael J. Hylin, Lucas D. Pozzo‐Miller, Camilo Hurtado‐Parrado · 2026 · BMC Neuroscience
- Temporal reorganization of maternal care during early life stress in miceHannah Jo, Eman Ali, Catherine J. Peña · 2026 · Neurobiology of Stress
- Effects of Serotonin Transporter Genotype and (Un)Predictable Maternal Separation on Affective, Cognitive, and Social Behaviors in Female RatsDanielle J. Houwing, Mayerli Andrea Prado-Rivera, Jenny Borkent, Marrit Gerbrandy, Chantal Arling, Berend Olivier · 2026 · Genes Brain & Behavior
- The Predictive Value of Infant Ultrasonic Vocalizations in a Longitudinal Study of Maternal Separation in RatsBahar Yuksel, Güneş Ünal · 2026 · Developmental Psychobiology