The DOI matches its Crossref record; 224 of the 226 references it cites were found in a registry or an index.
Early life stress, air pollution, inflammation, and disease: An integrative review and immunologic model of social-environmental adversity and lifespan health
Open accessAbstract
Socially disadvantaged individuals are at greater risk for simultaneously being exposed to adverse social and environmental conditions. Although the mechanisms underlying joint effects remain unclear, one hypothesis is that toxic social and environmental exposures have synergistic effects on inflammatory processes that underlie the development of chronic diseases, including cardiovascular disease, diabetes, depression, and certain types of cancer. In the present review, we examine how exposure to two risk factors that commonly occur with social disadvantage-early life stress and air pollution-affect health. Specifically, we identify neuroimmunologic pathways that could link early life stress, inflammation, air pollution, and poor health, and use this information to propose an integrated, multi-level model that describes how these factors may interact and cause health disparity across individuals based on social disadvantage. This model highlights the importance of interdisciplinary research considering multiple exposures across domains and the potential for synergistic, cross-domain effects on health, and may help identify factors that could potentially be targeted to reduce disease risk and improve lifespan health.
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“SCI during pregnancy and childhood can have serious developmental consequences that include elevating the risk of non-communicable diseases over the life span7,8,26,27.”
From Chronic inflammation in the etiology of disease across the life span (2019) · cites this paper as [27]
In the citing paper
“childhood circumstances significantly impact metabolic and immune responses later in life, which in turn promote SCI in adulthood8,26,27,168,169”
From Chronic inflammation in the etiology of disease across the life span (2019) · cites this paper as [27]
In the citing paper
“exposure to psychological stress early in life—for example, in the form of abuse, neglect, maltreatment, bullying or living in a low socioeconomic environment—can heighten neural responses to threat that can upregulate inflammatory activity170, alter immuno-competence and lead to SCI throughout the lifecycle27,169”
From Chronic inflammation in the etiology of disease across the life span (2019) · cites this paper as [27]
In the citing paper
“Early life and childhood exposure to antibiotics, vaccination, diet, smoke, and psychosocial stress seems to lead to a long-term adverse influence throughout life.”
From Stress triggers flare of inflammatory bowel disease in children and adults (2019) · cites this paper as [72]
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Cites
Felitti, V. J., Anda, R. F., Nordenberg, D., Williamson, D. F., Spitz, A. M., Edwards, V., Koss, M. P., & Marks, J. S. (1998) · American Journal of Preventive Medicine · doi:10.1016/s0749-3797(98)00017-8 · Cited by 18,943 · cited 8×
“…compared to individuals experiencing none of these types of adversity, and a 4- to 12-fold increase in risk for smoking, self-rated health complaints, alcoholism, drug abuse, depression, heart disease, and suicide (Anda et al., 2008; Dong et al., 2004; Dube et al., 2009; Felitti et al., 1998).”
BackgroundInfluentialMantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008) · Nature · doi:10.1038/nature07205 · Cited by 11,399 · cited 1×
“Indeed, several psychiatric disorders including substance abuse, post-traumatic stress disorder, depression, and schizophrenia have been linked to both early adversity exposure and inflammation, as have many somatic conditions, such as metabolic, cardiovascular, neoplastic, and rheumatic diseases (Anda et al., 2008, 2…”
Child abuse: Adolescent records vs. adult recall
Femina, D. D., Yeager, C. A., & Lewis, D. O. (1990) · Child Abuse & Neglect · doi:10.1016/0145-2134(90)90033-p · Cited by 8,820
Protective and Damaging Effects of Stress Mediators
McEwen, B. S. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801153380307 · Cited by 6,733 · cited 2×
“, IL-6, TNFα)- on cellular activities (enzyme, receptor, ion channel, genomic) (Juster et al., 2010; McEwen, 1998; McEwen and Wingfield, 2003).”
Epigenetic programming by maternal behavior
Weaver, I. C. G., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., & Meaney, M. J. (2004) · Nature Neuroscience · doi:10.1038/nn1276 · Cited by 6,177
Hughes, K., Bellis, M. A., Hardcastle, K. A., Sethi, D., Butchart, A., Mikton, C., Jones, L., & Dunne, M. P. (2017) · The Lancet Public Health · doi:10.1016/s2468-2667(17)30118-4 · Cited by 5,255 · cited 1×
“In this context, the terms early life stress or early adversity, have referred to different types of stressors, including violence, poverty, maltreatment, abuse, and neglect, as well as parental substance abuse or mental illness (Carroll et al., 2011; Dube et al., 2001; Hughes et al., 2017; Infurna et al., 2016; Lacey…”
The Lifelong Effects of Early Childhood Adversity and Toxic Stress
Shonkoff, J. P., Garner, A. S., THE COMMITTEE ON PSYCHOSOCIAL ASPECTS OF CHILD AND FAMILY HEALTH, C. O. E. C., Siegel, B. S., Dobbins, M. I., Earls, M. F., Garner, A. S., McGuinn, L., Pascoe, J., & Wood, D. L. (2012) · Pediatrics · doi:10.1542/peds.2011-2663 · Cited by 5,164
Brunekreef, B., & Holgate, S. T. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11274-8 · Cited by 4,701
Anda, R. F., Felitti, V. J., Bremner, J. D., Walker, J. D., Whitfield, C., Perry, B. D., Dube, S. R., & Giles, W. H. (2006) · European archives of psychiatry and clinical neuroscience · doi:10.1007/s00406-005-0624-4 · Cited by 4,292
Inflammation, stress, and diabetes
Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143 · cited 1×
“Second, many of these diseases have an underlying inflammatory component (Danese et al., 2009; O’Neill et al., 2007; Slavich and Irwin, 2014; Wellen and Hotamisligil, 2005).”
Cited by
Sorted by citations
Chronic inflammation in the etiology of disease across the life span
Furman, D., Campisi, J., Verdin, E., Carrera-Bastos, P., Targ, S., Franceschi, C., Ferrucci, L., Gilroy, D. W., Fasano, A., Miller, G. W., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0675-0 · Cited by 4,915
Self-citationSlavich, G. M. (2020) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032816-045159 · Cited by 502
Self-citationLawrance, E. L., Thompson, R., Newberry Le Vay, J., Page, L., & Jennings, N. (2022) · International Review of Psychiatry · doi:10.1080/09540261.2022.2128725 · Cited by 500
Chen, P., Liu, H., Sun, Y., Li, J., Cui, W. Q., Liao, W., Zhang, W., Yuan, X., Wang, Z., Zhang, Y., et al. (2019) · Applied Catalysis B: Environmental · doi:10.1016/j.apcatb.2019.118545 · Cited by 334
Association of Air Pollution Exposure With Psychotic Experiences During Adolescence
Newbury, J. B., Arseneault, L., Beevers, S. D., Kitwiroon, N., Roberts, S., Pariante, C. M., Kelly, F. J., & Fisher, H. L. (2019) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2019.0056 · Cited by 210
Metadata
- Authors
- Olvera Alvarez, H. A., Kubzansky, L. D., Campen, M. J., & Slavich, G. M.
- Affiliations
- Harvard University (US)
- University of New Mexico (US)
- University of California, Los Angeles (US)
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 92
- Pages
- 226-242
- ISSN
- 0149-7634 (ISSN-L)
- PMC
- PMC6082389
- OpenAlex
- W2805640433
- Cited by
- 133
- References
- 226
- Citations by year
- 2026: 12 · 2025: 16 · 2024: 19 · 2023: 16 · 2022: 24 · 2021: 19 · 2020: 10 · 2019: 14 · 2018: 3
- FWCI
- 1.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuroscience & Biobehavioral Reviews (acceptedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Branco Weiss Fellowship â Society in Science
- National Institute of Environmental Health Sciences (R01 ES014639, 3R01ES014639-09S1)
- National Alliance for Research on Schizophrenia and Depression (23958)
- Brain and Behavior Research Foundation (K08 MH103443)
- National Center on Minority Health and Health Disparities
- Topics
- Social Sciences › Health › Health disparities and outcomes
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Sociology and Political Science › Environmental Justice and Health Disparities
- Keywords
- early life stress, air pollution, inflammation, social deprivation, health disparities, neuroimmunology, chronic disease, cardiovascular disease, diabetes mellitus, depression, cancer, lifespan health, multi-level model
- MeSH terms
- Air Pollution, Humans, Inflammation, Longevity, Social Environment, Stress, Psychological, Models, Immunological
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