Activity-dependent regulation of vesicular glutamate and GABA transporters: A means to scale quantal size
Abstract
The functional balance of glutamatergic and GABAergic signaling in neuronal cortical circuits is under homeostatic control. That is, prolonged alterations of global network activity leads to opposite changes in quantal amplitude at glutamatergic and GABAergic synapses. Such scaling of excitatory and inhibitory transmission within cortical circuits serves to restore and maintain a constant spontaneous firing rate of pyramidal neurons. Our recent work shows that this includes alterations in the levels of expression of vesicular glutamate (VGLUT1 and VGLUT2) and GABA (VIAAT) transporters. Other vesicle markers, such as synaptophysin or synapsin, are not regulated in this way. Endogenous regulation at the level of mRNA and synaptic protein controls the number of transporters per vesicle and hence, the level of vesicle filling with transmitter. Bidirectional and opposite activity-dependent regulation of VGLUT1 and VIAAT expression would serve to adjust the balance of glutamate and GABA release and therefore the level of postsynaptic receptor saturation. In some excitatory neurons and synapses, co-expression of VGLUT1 and VGLUT2 occurs. Bidirectional and opposite changes in the levels of two excitatory vesicular transporters would enable individual neocortical neurons to scale up or scale down the level of vesicular glutamate storage, and thus, the amount available for release at individual synapses. Regulated vesicular transmitter storage and release via selective changes in the l…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Glutamate transporter (VGlut) expression in the presynaptic terminal can be enhanced by activity blockade.
“For example, there is evidence that glutamate transporter (VGlut) expression in the presynaptic terminal can be enhanced by activity blockade (De Gois et al. 2005;Erickson et al. 2006), raising the possibility that in addition to adding more postsynaptic receptors, neurons might also package more neurotransmitters into each presynaptic vesicle; these two processes would then collaborate to scale”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Erickson et al. 2006
No citation lists for this paper
No citation lists for this paper yet — checked again daily.
References 94 · Cited by 89
- Authors
- Erickson, J. D., De Gois, S., Varoqui, H., Schafer, M. K.-H., & Weihe, E.
- Affiliations
- Louisiana State University Health Sciences Center New Orleans (US)
- Philipps University of Marburg (DE)
- Corresponding author
- Erickson, Jeffrey D.
- ORCID
- Erickson, Jeffrey D.
- Venue
- Neurochemistry International
- Publisher
- Elsevier BV
- Published
- 2006-05
- Volume
- 48
- Issue
- 6-7
- Pages
- 643-649
- ISSN
- 0197-0186 (ISSN-L)
- OpenAlex
- W1974988575
- Cited by
- 89
- References
- 94
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 7 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 5 · 2015: 7 · 2014: 3 · 2013: 4 · 2012: 4
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurochemistry International (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Bundesministerium für Bildung und Forschung (01GS01118)
- National Institutes of Health (1P29RR16816, NS36936)
- National Alliance for Research on Schizophrenia and Depression
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Keywords
- vesicular glutamate transporter, vesicular GABA transporter, VGLUT1, VGLUT2, activity-dependent regulation, quantal size, synaptic homeostasis, excitation-inhibition balance, neocortical pyramidal neurons, glutamate release, GABA release
- MeSH terms
- Animals, Cerebral Cortex, Homeostasis, Humans, Nerve Net, Neuronal Plasticity, Neurons, Synapses, Glutamic Acid, Vesicular Inhibitory Amino Acid Transport Proteins, Vesicular Glutamate Transport Protein 1, Vesicular Glutamate Transport Protein 2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
