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Cited by 71MicroRNA in disease regulationNeuroinflammation and Neurodegeneration MechanismsCancer-related molecular mechanisms research

All’s well that transcribes well: Non-coding RNAs and post-stroke brain damage

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Vemuganti, Raghu·2013·Neurochemistry International
DOI 10.1016/j.neuint.2013.07.014PMC PMC3805745
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Abstract

The mammalian genome is replete with various classes of non-coding (nc) RNA genes. Many of them actively transcribe, and their relevance to CNS diseases is just beginning to be understood. CNS is one of the organs in the body that shows very high ncRNAs activity. Recent studies demonstrated that cerebral ischemia rapidly changes the expression profiles of different classes of ncRNAs: including microRNA, long noncoding RNA and piwi-interacting RNA. Several studies further showed that post-ischemic neuronal death and/or plasticity/regeneration can be altered by modulating specific microRNAs. These studies are of interest for therapeutic development as they may contribute to identifying new ncRNA targets that can be modulated to prevent secondary brain damage after stroke.

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Authors
Vemuganti, R.
Affiliations
University of Wisconsin–Madison (US)
Corresponding author
Vemuganti, Raghu
ORCID
Vemuganti, Raghu
Venue
Neurochemistry International
Publisher
Elsevier BV
Published
2013-11
Volume
63
Issue
5
Pages
438-449
ISSN
0197-0186 (ISSN-L)
DOI
10.1016/j.neuint.2013.07.014
PMC
PMC3805745
OpenAlex
W1982373471
Cited by
71
References
190
Citations by year
2025: 3 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 7 · 2020: 9 · 2019: 11 · 2018: 4 · 2017: 12 · 2016: 6 · 2015: 5 · 2014: 5
FWCI
0.44
Type
journal article
Language
en
Open access
Locations
  • Neurochemistry International (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Neurological Disorders and Stroke (NS074444, R21NS079585, NS079585, R21NS061071, R01NS064034, R21NS074444)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Keywords
non-coding RNA, microRNA, long non-coding RNA, piRNA, stroke, cerebral ischemia, blood-based biomarkers, neuronal cell death, neuroplasticity, stroke therapy targets
MeSH terms
Animals, Humans, Transcription, Genetic, Stroke, RNA, Untranslated

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