The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Effects of intraduodenal injection of Lactobacillus johnsonii La1 on renal sympathetic nerve activity and blood pressure in urethane-anesthetized rats.
Abstract
Previously, it was shown that milk fermented with lactic acid bacteria lowers blood pressure, suggesting that metabolites or components of the bacteria have hypotensive action. To examine whether one of lactobacilli, Lactobacillus johnsonii La1 (LJLa1), a probiotic strain adhesive onto intestinal epithelial cells, or its metabolite has hypotensive action, and if so the mechanism of action, we determined the effects of intraduodenal injection of LJLa1 on blood pressure (BP) and the activity of autonomic nerves in urethane-anesthetized rats. Intraduodenal injection of LJLa1 reduced renal sympathetic nerve activity (RSNA) and BP and enhanced gastric vagal nerve activity (GVNA). Pre-treatment with thioperamide, a histaminergic H3-receptor antagonist, eliminated the effects of LJLa1 on RSNA, GVNA, and BP. Furthermore, bilateral lesions of the hypothalamic suprachiasmatic nucleus (SCN), the master circadian oscillator, abolished the suppression of RSNA and BP and the elevation of GVNA caused by LJLa1. These findings suggest that LJLa1 or its metabolites might lower BP by changing autonomic neurotransmission via the central histaminergic nerves and the suprachiasmatic nucleus in rats.
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“It has become apparent that commensal bacteria can signal to local sensory neurons to alter their excitability state, which itself can last long after the bacteria have been removed (Tanida et al., 2005)”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Tanida et al., 2005
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Cites
The rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor
Arrang, J., Garbarg, M., & Schwartz, J. (1983) · Nature · doi:10.1038/302832a0 · Cited by 1,584
Seppo, L., Jauhiainen, T., Poussa, T. A., & Korpela, R. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.2.326 · Cited by 670
A detailed mapping of the histamine H3 receptor and its gene transcripts in rat brain
Pillot, C., Héron, A., Cochois, V., Tardivel‐Lacombe, J., Ligneau, X., Schwartz, J. C., & Arrang, J. M. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00135-5 · Cited by 340
Probiotics, infection and immunity
Macfarlane, G. T., & Cummings, J. H. (2002) · Current Opinion in Infectious Diseases · doi:10.1097/00001432-200210000-00008 · Cited by 185
Sipola, M., Finckenberg, P., Santisteban, J., Korpela, R., Vapaatalo, H., & Nurminen, M. L. (2001) · PubMed · Cited by 162
Chapter 8 Role of medulla oblongata in generation of sympathetic and vagal outflows
Guyenet, P. G., Koshiya, N., Huangfu, D., Baraban, S. C., Stornetta, R. L., & Li, Y. (1996) · Progress in brain research · doi:10.1016/s0079-6123(08)61862-2 · Cited by 147
Nagai, K., Nagai, N., Shimizu, K., Chun, S.-J., Nakagawa, H., & Niijima, A. (1996) · Progress in brain research · doi:10.1016/s0079-6123(08)60413-6 · Cited by 143
Self-citationSubstance P in the nucleus of the solitary tract augments bronchopulmonary C fiber reflex output
Mutoh, T., Bonham, A. C., & Joad, J. P. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.4.r1215 · Cited by 102
Research works printed but not linked: 1
- T. Yamano, H. Iino, M. Takada, S. Blum, F. Rochat, Y. Fukushima, Improvement of the human intestinal microflora by ingestion of the probiotic strain Lactobacillus johnsonii, Br. J. Nutr., in press.
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Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572
Gut microbiota in cardiovascular health and disease
Tang, W. H. W., Kitai, T., & Hazen, S. L. (2017) · Circulation Research · doi:10.1161/circresaha.117.309715 · Cited by 1,670
Gut/brain axis and the microbiota
Mayer, E. A., Tillisch, K., & Gupta, A. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76304 · Cited by 1,503
The vagus nerve at the interface of the microbiota-gut-brain axis
Bonaz, B., Bazin, T., & Pellissier, S. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00049 · Cited by 1,397
Metadata
- Authors
- Tanida, M., Yamano, T., Maeda, K., Okumura, N., Fukushima, Y., & Nagai, K.
- Affiliations
- Institute for Protein Research, The University of Osaka (JP)
- Corresponding author
- Nagai, Katsuya
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2005-12
- Volume
- 389
- Issue
- 2
- Pages
- 109-114
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2002714430
- Cited by
- 159
- References
- 18
- Citations by year
- 2026: 3 · 2025: 12 · 2024: 10 · 2023: 12 · 2022: 12 · 2021: 9 · 2020: 8 · 2019: 8 · 2018: 12 · 2017: 11 · 2016: 7 · 2015: 3 · 2014: 8 · 2013: 10 · 2012: 7
- FWCI
- 8.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- probiotics, renal sympathetic nerve activity, blood pressure, histamine H3 receptor, thioperamide, suprachiasmatic nucleus, circadian rhythm, autonomic neurotransmission, gut-brain axis, antihypertensive effect
- MeSH terms
- Adrenergic Fibers, Animals, Blood Pressure, Denervation, Duodenum, Histamine, Histamine Antagonists, Kidney, Lactobacillus, Male, Neural Pathways, Reaction Time, Suprachiasmatic Nucleus, Urethane, Vagus Nerve, Yogurt, Rats, Wistar, Receptors, Histamine H3, Anesthetics, Intravenous, Rats
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