p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells
Open accessAbstract
p53 and tau are both associated with neurodegenerative disorders. Here, we show by Western blotting that p53 is upregulated approximately 2-fold in the superior temporal gyrus of Alzheimer's patients compared to healthy elderly control subjects. Moreover, p53 was found to induce phosphorylation of human 2N4R tau at the tau-1/AT8 epitope in HEK293a cells. Confocal microscopy revealed that tau and p53 were spatially separated intracellularly. Tau was found in the cytoskeletal compartment, whilst p53 was located in the nucleus, indicating that the effects of p53 on tau phosphorylation are indirect. Collectively, these findings have ramifications for neuronal death associated with Alzheimer's disease and other tauopathies.
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A mutation of either DFAN5 or TRIM22 may affect this pathway and result in the upregulation of p53 in AD.
“A mutation of either of these genes may affect this pathway and result in the upregulation of p53 in AD.43”
From APOE*E2 allele delays age of onset in PSEN1 E280A Alzheimer’s disease (2016) · cites this paper as [43]
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References 15 · Cited by 165
- Authors
- Hooper, C., Meimaridou, E., Tavassoli, M., Melino, G., Lovestone, S., & Killick, R.
- Affiliations
- King's College London (GB)
- University of Rome Tor Vergata (IT)
- Corresponding author
- Killick, Richard
- ORCID
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2007-05
- Volume
- 418
- Issue
- 1
- Pages
- 34-37
- ISSN
- 0304-3940 (ISSN-L)
- PMC
- PMC1885960
- OpenAlex
- W2041278398
- Cited by
- 165
- References
- 15
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 11 · 2023: 9 · 2022: 17 · 2021: 9 · 2020: 21 · 2019: 2 · 2018: 16 · 2017: 15 · 2016: 8 · 2015: 10 · 2014: 5 · 2013: 9 · 2012: 5
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Wellcome Trust
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- p53, tau phosphorylation, Alzheimer's disease, tauopathy, superior temporal gyrus, neuronal cell death, neurodegeneration
- MeSH terms
- Aged, Alzheimer Disease, Fluorescent Antibody Technique, Humans, Phosphorylation, Temporal Lobe, Blotting, Western, Tumor Suppressor Protein p53, tau Proteins, Microscopy, Confocal, Cell Line, Tumor
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