Chronic toxic demyelination in the central nervous system leads to axonal damage despite remyelination

Lindner, Maren; Fokuhl, Jantje; Linsmeier, Franziska; Trebst, Corinna; Stangel, Martin

doi:10.1016/j.neulet.2009.02.004

Chronic toxic demyelination in the central nervous system leads to axonal damage despite remyelination

The majority of multiple sclerosis lesions fail to remyelinate after chronic demyelinating episodes resulting in neurologic disability. In the current study, chronic demyelination was investigated by using the cuprizone model, a toxic demyelination model. C57BL/6 mice were administered a 0.2% cup…