Human clinical trails in antiepileptogenesis
Open accessAbstract
Blocking the development of epilepsy (epileptogenesis) is a fundamental research area with the potential to provide large benefits to patients by avoiding the medical and social consequences that occur with epilepsy and lifelong therapy. Human clinical trials attempting to prevent epilepsy (antiepileptogenesis) have been few and universally unsuccessful to date. In this article, we review data about possible pathophysiological mechanisms underlying epileptogenesis, discuss potential interventions, and summarize prior antiepileptogenesis trials. Elements of ideal trials designs for successful antiepileptogenic intervention are suggested.
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There are no effective treatments or preventive/disease-modifying therapies for TLE or epileptogenesis.
“Aside from neurosurgical resection, which benefits only a small population of TLE patients [2], there are no other effective treatments or preventive strategies for TLE [3].”
From Hippocampal neuro-networks and dendritic spine perturbations in epileptogenesis are attenuated by neuroprotectin D1 (2015) · cites this paper as [3]
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References 45 · Cited by 51
- Authors
- Mani, R., Pollard, J., & Dichter, M. A.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Dichter, Marc A.
- ORCID
- Mani, Ram
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 497
- Issue
- 3
- Pages
- 251-256
- ISSN
- 0304-3940 (ISSN-L)
- PMC
- PMC3138332
- OpenAlex
- W2119967224
- Cited by
- 51
- References
- 45
- Citations by year
- 2026: 1 · 2023: 1 · 2022: 1 · 2021: 5 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 6 · 2016: 3 · 2015: 6 · 2014: 6 · 2013: 8 · 2012: 2
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r01ns041811-10)
- National Institute of Neurological Disorders and Stroke (R01 NS-041811)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Health Sciences › Medicine › Physiology › Diet and metabolism studies
- Keywords
- antiepileptogenesis, epileptogenesis, epilepsy prevention, clinical trial design
- MeSH terms
- Anticonvulsants, Brain, Clinical Trials as Topic, Epilepsy, Humans, Treatment Outcome
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