MiR-335 is involved in major depression disorder and antidepressant treatment through targeting GRM4
Abstract
Major depressive disorder (MDD) is a prevalent mood disorder. Treatment of MDD includes a variety of biopsychosocial approaches. Glutamate receptor, metabotropic 4 (GRM4) has been implicated in the regulation of MDD and it is seen as an attractive target for drug discovery and development. Here we reported using cellular assays and blood samples from MDD patients and showed that miR-335 was downregulated in individuals with depression compared with healthy controls. Additionally, we confirmed that miR-335 can directly target GRM4, which can further regulated the expression of miR-335. Antidepressant drug treatment with citalopram can upregulate miR-335 expression and downregulate GRM4 expression. These results suggest that miR-335 is associated with the pathophysiology of depression and is a potential target for new antidepressant treatments.
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miR-335, miR-1202, miR-29b-3p, and miR-134-5p may regulate depression through inhibiting GRM4 expression, affecting Ca2+ influx into prefrontal cortex neurons and extracellular glutamate concentration.
“MiR-335, miR-1202, miR-29b-3p, and miR-134-5p may regulate depression through inhibiting the expression of GRM4 gene (Fig. 5), that in turn affect the influx of Ca2+ into the prefrontal cortex neurons and the extracellular concentration of glutamate.277–283”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [279]
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References 33 · Cited by 73
- Authors
- Li, J., Meng, H., Cao, W., & Qiu, T.
- Affiliations
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Corresponding author
- Meng, Huaqing
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 606
- Pages
- 167-172
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W1151380674
- Cited by
- 73
- References
- 33
- Citations by year
- 2026: 3 · 2024: 15 · 2023: 8 · 2022: 8 · 2021: 9 · 2020: 6 · 2019: 8 · 2018: 3 · 2017: 7 · 2016: 6
- FWCI
- 3.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- miR-335, major depressive disorder, mGluR4, citalopram, antidepressant treatment, microRNA downregulation, depression pathophysiology, antidepressant targets
- MeSH terms
- Adolescent, Antidepressive Agents, Child, Depressive Disorder, Major, Major Depressive Disorder, Female, Fluoxetine, Humans, Male, Citalopram, Case-Control Studies, Receptors, Metabotropic Glutamate, MicroRNAs, HEK293 Cells, Neural Stem Cells, Molecular Targeted Therapy
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