Electrophysiological responses of feedback processing are modulated by MAOA genotype in healthy male adolescents
Abstract
A functional polymorphism in the promoter region of the monoamine oxidase A (MAOA) gene is closely related to aggression. Although previous studies suggested that impaired ability of feedback processing might be associated with aggressive behaviour, studies concerning the MAOA gene-related aggression rarely focused on the link between MAOA gene and feedback processing. We therefore sought to investigate the effect of MAOA genotype on electrophysiological responses of feedback processing in 72 healthy male adolescents during a simple monetary gambling task. Feedback processing was investigated by measuring the feedback-related negativity (FRN) and the P300 as electrophysiological markers. We observed a decreased electrophysiological response of the loss-gain difference waves from 250 to 350 ms (dFRN) in individuals with the lower activity alleles (MAOA-L) during the task, an effect that was driven primarily by the considerably altered response to monetary gains. The reduced dFRN in MAOA-L group might indicate poor ability to learn from feedback, which is followed by adjusting future behaviour. And MAOA-L carriers exhibited lower P300 compared with subjects with higher activity alleles (MAOA-H), which suggested fewer attentional resources were allocated to feedback processing. In addition, MAOA-L carriers demonstrated higher aggression and the aggression were inversely correlated with dFRN across two groups; further analyses suggested that dFRN mediated the MAOA genotype-aggression relationship. Consequently, we concluded that it might be the altered feedback processing that makes MAOA-L carriers more vulnerable to aggressive behaviour.
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MAOA-L was associated with higher aggression, which was inversely correlated with dFRN across two groups.
“MAOA-L associated with higher aggression, which was inversely correlated with dFRN across two groups.”
From Genetics of child aggression, a systematic review (2024) · cites this paper as Ma [44]
Compared with MAOA-H group, BPAQ-C total scores in MAOA-L group were significantly higher [t(70) = 2.630, p = 0.010], similarly observed both the anger and hostility subscales [anger: t(70) = 2.150, p = 0.035; hostility: t(70) = 2.048, p = 0.044].
“Compared with MAOA-H group, BPAQ-C total scores in MAOA-L group were significantly higher [t(70) = 2.630, p = 0.010], similarly observed both the anger and hostility subscales [anger: t(70) = 2.150, p = 0.035; hostility: t(70) = 2.048, p = 0.044].”
From Genetics of child aggression, a systematic review (2024) · cites this paper as Ma [44]
Different studies have found the low-expression (2 R, 3 R, and 5 R) MAOA-uVNTR to be associated with childhood aggression, although their categorization of low-expression alleles differs.
“Similarly, different studies have also found that the low-expression (2 R, 3 R, and 5 R) MAOA-uVNTR to be associated with childhood aggression, although their categorization of low-expression alleles differ [44].”
From Genetics of child aggression, a systematic review (2024) · cites this paper as [44]
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References 33 · Cited by 5
- Authors
- Ma, R., Jia, H., Yi, F., Ming, Q., Wang, X., Gao, Y., Yi, J., & Yao, S.
- Affiliations
- Central South University (CN)
- Corresponding author
- Yao, Shuqiao
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 610
- Pages
- 144-149
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2194800632
- Cited by
- 5
- References
- 33
- Citations by year
- 2025: 1 · 2024: 1 · 2020: 1 · 2018: 1 · 2017: 1
- FWCI
- 0.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Key Technologies R&D Program (2009BAI77B02)
- Natural Science Foundation of China (81471384)
- Specialized Research Fund for the Doctoral Program of Higher Education (20130162110043)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Keywords
- monoamine oxidase A, feedback processing, aggression, feedback-related negativity, P300, learning from feedback, attentional resources, adolescents, gene-environment interaction
- MeSH terms
- Adolescent, Adolescent Behavior, Aggression, Evoked Potentials, Gambling, Genotype, Humans, Male, Monoamine Oxidase, Feedback, Psychological
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