Intrathecal insulin-like growth factor 1 but not insulin enhances myelin repair in young and aged rats

Hlavica, Martin; Delparente, Aro; Good, Andrin; Good, Nicolas; Plattner, Patricia S.; Seyedsadr, Maryam S.; Schwab, Martin E.; Figlewicz, Dianne P.; Ineichen, Benjamin V.

doi:10.1016/j.neulet.2017.03.047

Intrathecal insulin-like growth factor 1 but not insulin enhances myelin repair in young and aged rats

One main pathological hallmark of multiple sclerosis (MS) is demyelination. Novel therapies which enhance myelin repair are urgently needed. Insulin and insulin-like growth factor 1 (IGF-1) have strong functional relationships. Here, we addressed the potential capacity of IGF-1 and insulin to enh…