The DOI matches its Crossref record; 294 of the 294 references it cites were found in a registry or an index.
The complexity of tau in Alzheimer’s disease
Open accessAbstract
Alzheimer’s disease (AD) is characterized by two major pathological lesions in the brain, amyloid plaques and neurofibrillary tangles (NFTs) composed mainly of amyloid-β (Aβ) peptides and hyperphosphorylated tau, respectively. Although accumulation of toxic Aβ species in the brain has been proposed as one of the important early events in AD, continued lack of success of clinical trials based on Aβ-targeting drugs has triggered the field to seek out alternative disease mechanisms and related therapeutic strategies. One of the new approaches is to uncover novel roles of pathological tau during disease progression. This review will primarily focus on recent advances in understanding the contributions of tau to AD.
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Cites
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Cited by
Ronaldson, P. T., & Davis, T. P. (2020) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x20951995 · Cited by 392
Alzheimer’s Disease and Inflammaging
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In vivo synaptic density loss is related to tau deposition in amnestic mild cognitive impairment
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Metadata
- Authors
- Naseri, N. N., Wang, H., Guo, J., Sharma, M., & Luo, W.
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2019-07
- Volume
- 705
- Pages
- 183-194
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2941198005
- Cited by
- 373
- References
- 294
- FWCI
- 19.72
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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