Beta-amyloid activates NLRP3 inflammasome via TLR4 in mouse microglia

Liu, Yang; Dai, Yue; Li, Qing; Chen, Chen; Chen, Hao; Song, Yuanjian; Hua, Fang; Zhang, Zuohui

doi:10.1016/j.neulet.2020.135279

Beta-amyloid activates NLRP3 inflammasome via TLR4 in mouse microglia

Beta-amyloid(Aβ)-induced inflammation plays a critical role in the pathogenesis of Alzheimer's disease (AD). Nod-like receptor nucleotide-binding domain leucine rich repeat containing protein 3 (NLRP3) inflammasome is involved in the Aβ-induced inflammation. However, the mechanisms by which extra…