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Cited by 40

MicroRNA-140 silencing represses the incidence of Alzheimer’s disease

Liang, Chunming, Mu, Yuyuan, Tian, Hua, Wang, Dan, Zhang, Shicun, Wang, Hongjiao, Liu, Yang, Di, Cihan·2021·Neuroscience Letters
DOI 10.1016/j.neulet.2021.135674
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Abstract

Alzheimer's disease (AD) is a neurodegenerative condition leading to severe disability from progressive impairments in cognitive functions including memory and learning. Non-coding microRNAs (miRNAs or miRs) have been linked to the pathogenesis of AD. The present study aimed to investigate the clinical significance and biological function of miR-140 in AD. First, we examined the expression of miR-140 and PINK1 in brain tissues of the established AD model rats and neurons cultured with Aβ-derived diffusible ligands (AβDDLs). We identified an interaction between miR-140 and PINK1, and measured spatial learning and memory abilities of the model rats using the Morris water maze (MWM) test. After ectopic expression and depletion experiments in neurons and AD rats, we measured the levels of reactive oxygen species (ROS), and mitochondrial membrane potential (MMP), along with mTOR expression and phosphorylation, and autophagy-related factors. Results showed up-regulation of miR-140 and down-regulation of PINK1 in AD model rats and neurons. PINK1 was verified to be a direct target of miR-140, and silencing of miR-140 suppressed mitochondrial dysfunction, and enhanced autophagy in AD model rats and neurons, as supported by decreased levels of mTOR expression and phosphorylation, β-amyloid p-Tau (Ser396), p-Tau (Thr231), Tau and ROS, and increased MMP levels and expression of Beclin 1 expression and LC3-II/LC3-I. Collectively, functional suppression of miR-140 enhanced autophagy and pr…

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Crossref · 10.1016/j.neulet.2021.135674

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  • miR-140-5p disrupts PINK1-regulated mitophagy, and miR-199a-5p suppresses neuritin, limiting synaptic regeneration.

    “Additionally, miR-140-5p disrupts PINK1-regulated mitophagy, and miR-199a-5p suppresses neuritin, limiting synaptic regeneration (Liang et al., 2021; Song et al., 2020).”

    From Cell-specific MicroRNA networks orchestrate the pathogenesis of Alzheimer’s disease (2026) · cites this paper as Liang et al., 2021

  • Hypoxia-responsive miR-210 is induced in metabolically stressed astrocytes, where it targets ISCU and components of the mitochondrial respiratory chain, shifting astrocytes toward glycolysis and weakening oxidative metabolic support for neurons.

    “On the other hand, hypoxia-responsive miR-210 is induced in metabolically stressed astrocytes, where it targets ISCU and components of the mitochondrial respiratory chain, shifting astrocytes toward glycolysis and weakening oxidative metabolic support for neurons (Liang et al., 2021).”

    From Cell-specific MicroRNA networks orchestrate the pathogenesis of Alzheimer’s disease (2026) · cites this paper as Liang et al., 2021

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Authors
Liang, C., Mu, Y., Tian, H., Wang, D., Zhang, S., Wang, H., Liu, Y., & Di, C.
ORCID
Liang, Chunming
Venue
Neuroscience Letters
Publisher
Elsevier BV
Published
2021-07
Volume
758
Pages
135674
ISSN
0304-3940
DOI
10.1016/j.neulet.2021.135674
Cited by
40
References
2
Language
en
Licence
Funders
  • National Natural Science Foundation of China (81803757, H2017079)
  • Heilongjiang Provincial Science and Technology Department (81803757, H2017079)

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