The DOI matches its Crossref record; 48 of the 49 references it cites were found in a registry or an index.
Inter- and intra-laminar connections of pyramidal cells in the neocortex.
Abstract
The flow of excitation through cortical columns has long since been predicted by studying the axonal projection patterns of excitatory neurones situated within different laminae. In grossly simplified terms and assuming random connectivity, such studies predict that input from the thalamus terminates primarily in layer 4, is relayed 'forward' to layer 3, then to layers 5 and 6 from where the modified signal may exit the cortex. Projection patterns also indicate 'back' projections from layer 5 to 3 and layer 6 to 4. More recently it has become clear that the interconnections between these layers are not random; forward projections primarily contact specific pyramidal subclasses and intracortical back projections innervate interneurones. This indicates that presynaptic axons or postsynaptic dendrites are capable of selecting their synaptic partners and that this selectivity is layer dependent. For the past decade, we and others have studied pyramidal cell targeting in circuits both within, and between laminae using paired intracellular recordings with biocytin filling and have begun to identify further levels of selectivity through the preferential targeting of electrophysiologically and/or morphologically distinct pyramidal subtypes. Presented here, therefore, is a brief overview of current thinking on the layer and subclass specific connectivity of neocortical principle excitatory cells.
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In the citing paper
“In biology, it is found that axons of the layer 2/3 pyramidal neurons travel several millimeters parallel to the layer 2/3 – layer 4 boundary and re-enter layer 2/3 to make excitatory connections to pyramidal cells there [43],[48].”
From Towards a mathematical theory of cortical micro-circuits (2009) · cites this paper as [43]
In the citing paper
“In addition, the layer 2/3 neurons receive excitatory inputs from other layer 2/3 neurons via extensive lateral connections [43].”
From Towards a mathematical theory of cortical micro-circuits (2009) · cites this paper as [43]
In the citing paper
“It is also known that the RS cells are mostly pre-synaptic to the IB cells [43].”
From Towards a mathematical theory of cortical micro-circuits (2009) · cites this paper as [43]
In the citing paper
“The output of the RS cell goes to the IB cell.”
From Towards a mathematical theory of cortical micro-circuits (2009) · cites this paper as [43]
Citations
Cites
Two networks of electrically coupled inhibitory neurons in neocortex
Gibson, J. R., Beierlein, M., & Connors, B. W. (1999) · Nature · doi:10.1038/47035 · Cited by 1,404
Columnar specificity of intrinsic horizontal and corticocortical connections in cat visual cortex
Gilbert, C., & Wiesel, T. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-07-02432.1989 · Cited by 1,166
Laminar origins and terminations of cortical connections of the occipital lobe in the rhesus monkey
Rockland, K. S., & Pandya, D. Ν. (1979) · Brain Research · doi:10.1016/0006-8993(79)90485-2 · Cited by 1,076
Recurrent Excitation in Neocortical Circuits
Douglas, R. J., Christof Koch, A., Mahowald, M. A., Martin, K. A. C., & Suarez, H. H. (1995) · Science · doi:10.1126/science.7638624 · Cited by 985
NMDA spikes in basal dendrites of cortical pyramidal neurons
Schiller, J., Major, G., Koester, H. J., & Schiller, Y. (2000) · Nature · doi:10.1038/35005094 · Cited by 720
The thalamic matrix and thalamocortical synchrony
Jones, E. G. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01922-6 · Cited by 688
Lund, J. S., Lund, R. D., Hendrickson, A. E., Milam, A. H., & Fuchs, A. F. (1975) · The Journal of Comparative Neurology · doi:10.1002/cne.901640303 · Cited by 681
Structure, development, and plasticity of dendritic spines
Harris, K. M. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)80050-6 · Cited by 523
Organization of neurons in the visual cortex, area 17, of the monkey (Macaca mulatta)
Lund, J. S. (1973) · The Journal of Comparative Neurology · doi:10.1002/cne.901470404 · Cited by 505
Feldmeyer, D., Egger, V., Lübke, J., & Sakmann, B. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.00169.x · Cited by 441
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1 of the 49 references couldn’t be matched to a known paper.
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- Feldman, 1984, Morphology of the neocortical neuron, vol. 1, 123
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Antal, A., & Paulus, W. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00317 · Cited by 625
The preclinical phase of the pathological process underlying sporadic Alzheimer’s disease
Braak, H., & Del Tredici, K. (2015) · Brain · doi:10.1093/brain/awv236 · Cited by 540
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Jia, H., Rochefort, N. L., Chen, X., & Konnerth, A. (2010) · Nature · doi:10.1038/nature08947 · Cited by 521
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Metadata
- Authors
- Bannister, A. P.
- Affiliations
- University of London (GB)
- Corresponding author
- Bannister, A. Peter
- Venue
- Neuroscience Research
- Publisher
- Elsevier BV
- Published
- 2005-10
- Volume
- 53
- Issue
- 2
- Pages
- 95-103
- ISSN
- 0168-0102 (ISSN-L)
- OpenAlex
- W2039265322
- Cited by
- 138
- References
- 49
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 3 · 2023: 6 · 2022: 7 · 2021: 3 · 2020: 10 · 2019: 7 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 14 · 2014: 8 · 2013: 5 · 2012: 5
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- pyramidal neurons, neocortex, intracortical connections, cortical columns, axonal projection patterns, thalamocortical connections, back-projection, interneurons
- MeSH terms
- Animals, Humans, Neural Pathways, Pyramidal Cells, Neocortex
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