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Selective cognitive dysfunction in mice lacking histamine H1 and H2 receptors
Abstract
Previous pharmacological experiments provide conflicting findings that describe both facilitatory and inhibitory effects of neuronal histamine on learning and memory. Here, we examined learning and memory and synaptic plasticity in mice with a null mutation of gene coding histamine H1 or H2 receptor in order to clarify the role of these receptors in learning and memory processes. Learning and memory were evaluated by several behavioral tasks including object recognition, Barnes maze and fear conditioning. These behavioral tasks are highly dependent on the function of prefrontal cortex, hippocampus or amygdala. Object recognition and Barnes maze performance were significantly impaired in both H1 receptor gene knockout (H1KO) and H2 receptor gene knockout (H2KO) mice when compared to the respective wild-type (WT) mice. Conversely, both H1KO and H2KO mice showed better auditory and contextual freezing acquisition than their respective WT mice. Furthermore, we also examined long-term potentiation (LTP) in the CA1 area of hippocampus in H1KO and H2KO mice and their respective WT mice. LTP in the CA1 area of hippocampus was significantly reduced in both H1KO and H2KO mice when compared with their respective WT mice. In conclusion, our results demonstrate that both H1 and H2 receptors are involved in learning and memory processes for which the frontal cortex, amygdala and hippocampus interact.
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“In histamine H1-R and H2-R knockout mice, LTP in the hippocampus CA1 area was decreased together with impairment of NOP memory”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Dai et al., 2007
Citations
Cites
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444
Memory deficits associated with senescence: A neurophysiological and behavioral study in the rat.
Barnes, C. A. (1979) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077579 · Cited by 2,088
The physiology of brain histamine
Brown, R. E., Stevens, D. R., & Haas, H. L. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00039-3 · Cited by 996
The role of histamine and the tuberomamillary nucleus in the nervous system
Haas, H., & Panula, P. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1034 · Cited by 929
Watanabe, T., Taguchi, Y., Shiosaka, S., Tanaka, J., Kubota, H., Terano, Y., Tohyama, M., & Wada, H. (1984) · Brain Research · doi:10.1016/0006-8993(84)90811-4 · Cited by 820
Histamine-containing neurons in the rat hypothalamus.
Panula, P., Yang, H., & Costa, E. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.8.2572 · Cited by 738
Morgan, M. A., & LeDoux, J. E. (1995) · Behavioral Neuroscience · doi:10.1037/0735-7044.109.4.681 · Cited by 717
Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice
Anagnostaras, S., Murphy, G. G., Hamilton, S. E., Mitchell, S. L., Rahnama, N. P., Nathanson, N. M., & Silva, A. J. (2002) · Nature Neuroscience · doi:10.1038/nn992 · Cited by 551
Spatial learning and memory processes: the search for their neurobiological mechanisms in the rat
Barnes, C. A. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90143-9 · Cited by 429
Rosenkranz, J. A., Moore, H., & Grace, A. A. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-35-11054.2003 · Cited by 344
Impaired locomotor activity and exploratory behavior in mice lacking histamine H 1 receptors
Inoue, I., Yanai, K., Kitamura, D., Taniuchi, I., Kobayashi, T., Niimura, K., Watanabe, T., & Watanabe, T. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.23.13316 · Cited by 299
Identification of Rat H3 Receptor Isoforms with Different Brain Expression and Signaling Properties
Drutel, G., Peitsaro, N., Karlstedt, K. A., Wieland, K., Smit, M. J., Timmerman, H., Panula, P., & Leurs, R. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.1.1 · Cited by 288
The histamine H3 receptor as a novel therapeutic target for cognitive and sleep disorders
Passani, M. B., Lin, J., Hancock, A. A., Crochet, S., & Blandina, P. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.10.003 · Cited by 255
Lin, J., Hou, Y., Sakai, K., & Jouvet, M. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-04-01523.1996 · Cited by 234
Blandina, P., Giorgetti, M., Bartolini, L., Cecchi, M., Timmerman, H., Leurs, R., Pepeu, G., & Giovannini, M. G. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb16086.x · Cited by 234
Bouthenet, M.-L., Ruat, M., Salès, N., Garbarg, M., & Schwartz, J. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90167-4 · Cited by 178
Object recognition memory in the rat: the role of the hippocampus
Rothblat, L. A., & Kromer, L. F. (1991) · Behavioural Brain Research · doi:10.1016/s0166-4328(05)80036-1 · Cited by 167
Kobayashi, T., Tonai, S., Ishihara, Y., Koga, R., Okabe, S., & Watanabe, T. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9441 · Cited by 164
Yanai, K., Son, L. Z., Endou, M., Sakurai, E., Nakagawasai, O., Tadano, T., Kisara, K., Inoue, I., Watanabe, T., & Watanabe, T. (1998) · Neuroscience · doi:10.1016/s0306-4522(98)00167-5 · Cited by 154
Scopolamine-induced deficits in a two-trial object recognition task in mice
Dodart, J., Mathis, C., & Ungerer, A. (1997) · Neuroreport · doi:10.1097/00001756-199703240-00023 · Cited by 149
Histamine H1 receptors in patients with Alzheimer’s disease assessed by positron emission tomography
Higuchi, M., Yanai, K., Okamura, N., Meguro, K., Arai, H., Itoh, M., Iwata, R., Ido, T., Watanabe, T., & Sasaki, H. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00230-x · Cited by 147
Memory facilitation by histamine.
de Almeida, M. A. M. R., & Izquierdo, I. (1986) · PubMed · Cited by 136
Ruat, M., Traiffort, É., Bouthenet, M.-L., Schwartz, J., Hirschfeld, J., Buschauer, A., & Schunack, W. G. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.5.1658 · Cited by 134
Huston, J. P., Wagner, U. A. G., & Hasenöhrl, R. U. (1997) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)86052-4 · Cited by 134
Central histaminergic system and cognition
Passani, M. B., Bacciottini, L., Mannaioni, P. F., & Blandina, P. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00053-6 · Cited by 129
Influence of histamine depletion on learning and memory recollection in rats
KAMEI, C., Okumura, Y., & Tasaka, K. (1993) · Psychopharmacology · doi:10.1007/bf02244955 · Cited by 119
Functional neuroimaging of cognition impaired by a classical antihistamine, d‐chlorpheniramine
Okamura, N., Yanai, K., Higuchi, M., Sakai, J., Iwata, R., Ido, T., Sasaki, H., Watanabe, T., & Itoh, M. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702994 · Cited by 117
Yanai, K., Ryu, J. H., Watanabe, T., Iwata, R., Ido, T., Sawai, Y., Ito, K., & Itoh, M. (1995) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1995.tb16386.x · Cited by 110
Passani, M. B., Cangioli, I., Baldi, E., Bucherelli, C., Mannaioni, P. F., & Blandina, P. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01780.x · Cited by 102
Long-term increase of hippocampal excitability by histamine and cyclic AMP
Selbach, O., Brown, R. E., & Haas, H. L. (1997) · Neuropharmacology · doi:10.1016/s0028-3908(97)00144-5 · Cited by 101
Fox, G. B., Pan, J. B., Radek, R. J., Lewis, A. M., Bitner, R. S., Esbenshade, T. A., Faghih, R., Bennani, Y. L., Williams, M. J., Yao, B. B., et al. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.047241 · Cited by 100
Cangioli, I., Baldi, E., Mannaioni, P. F., Bucherelli, C., Blandina, P., & Passani, M. B. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02092.x · Cited by 97
Dere, E., Souza‐Silva, M. A. D., Topic, B., Spieler, R. E., Haas, H. L., & Huston, J. P. (2003) · Learning & Memory · doi:10.1101/lm.67603 · Cited by 93
Histaminergic modulation of synaptic plasticity in area CA1 of rat hippocampal slices
Brown, R. E., Fedorov, N. B., Haas, H. I., & Reymann, K. (1995) · Neuropharmacology · doi:10.1016/0028-3908(94)00138-i · Cited by 92
Dere, E., Souza‐Silva, M. A. D., Spieler, R. E., Lin, J., Ohtsu, H., Haas, H. L., & Huston, J. P. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03546.x · Cited by 92
Acetylcholine, Histamine, and Cognition: Two Sides of the Same CoinPreprint
Blandina, P., Efoudebe, M., Cenni, G., Mannaioni, P. F., & Passani, M. B. (2004) · Learning & Memory · doi:10.1101/lm.68004 · Cited by 91
Interactions between histaminergic and cholinergic systems in learning and memory
Bacciottini, L. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00230-3 · Cited by 90
Characterization of histamine H3receptors regulating acetylcholine release in rat entorhinal cortex
Arrang, J. M., Drutel, G., & Jc, S. (1995) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1995.tb13379.x · Cited by 87
Schneider, C., Risser, D., Kirchner, L., Kitzmüller, E., Cairns, N. J., Prast, H., Singewald, N., & Lübec, G. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)13379-1 · Cited by 71
Schwartz, J., & Haas, H. L. (1991) · Wiley-Liss eBooks · Cited by 69
Local GABAergic modulation of acetylcholine release from the cortex of freely moving rats
Giorgetti, M., Bacciottini, L., Giovannini, M. G., Colivicchi, M. A., Goldfarb, J., & Blandina, P. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00079.x · Cited by 68
Vouimba, R., Garcia, R., Baudry, M., & Thompson, R. F. (2000) · Behavioral Neuroscience · doi:10.1037//0735-7044.114.4.720 · Cited by 50
Ryu, J. H., Yanai, K., Sakurai, E., Kim, C.-Y., & Watanabe, T. (1995) · Developmental Brain Research · doi:10.1016/0165-3806(95)00055-i · Cited by 49
Nagase, T., Ito, K., Kato, K., Kaneko, K., Kohda, K., Matsumoto, M., Hoshino, A., Inoue, T., Fujii, S., Kato, H., et al. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00803-5 · Cited by 47
Vouimba, R., Garcia, R., Baudry, M., et al. (2000) · Behavioral Neuroscience · doi:10.1037/0735-7044.114.4.720 · Cited by 40
Vijayan, V. K. (1979) · Neuroscience · doi:10.1016/0306-4522(79)90222-7 · Cited by 39
Fujii, S., Kuroda, Y., Ito, K., KANEKO, K., & Kato, H. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.00451.x · Cited by 37
Giorgetti, M., Bacciottini, L., Bianchi, L., Giovannini, M. G., Cecchi, M., & Blandina, P. (1997) · Inflammation Research · doi:10.1007/s000110050044 · Cited by 35
Dai, H., Okuda, T., Sakurai, E., Kuramasu, A., Kato, M., Jia, F., Xu, A., Iinuma, K., Sato, I., & Yanai, K. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0203-4 · Cited by 33
Thioperamide and cimetidine modulate acetylcholine release from the amygdala of freely moving rats
Passani, M. B., Cangioli, I., Bacciottini, L., Mannaioni, P. F., & Blandina, P. (2000) · Inflammation Research · doi:10.1007/pl00000175 · Cited by 18
The Neuronal Histaminergic System in Cognition
Passani, M. B., & Blandina, P. (2004) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/1568015043477595 · Cited by 12
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Metadata
- Authors
- Dai, H., Kaneko, K., Kato, H., Fujii, S., Jing, Y., Xu, A., Sakurai, E., Kato, M., Okamura, N., Kuramasu, A., & Yanai, K.
- Affiliations
- Tohoku University (JP)
- Yamagata University (JP)
- Corresponding author
- Yanai, Kazuhiko
- ORCID
- Venue
- Neuroscience Research
- Publisher
- Elsevier BV
- Published
- 2007-02
- Volume
- 57
- Issue
- 2
- Pages
- 306-313
- ISSN
- 0168-0102 (ISSN-L)
- OpenAlex
- W2047066043
- Cited by
- 136
- References
- 50
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 7 · 2023: 3 · 2022: 5 · 2021: 7 · 2020: 3 · 2019: 3 · 2018: 7 · 2017: 7 · 2016: 10 · 2015: 5 · 2014: 11 · 2013: 12 · 2012: 8
- FWCI
- 3.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- histamine H1 receptor, histamine H2 receptor, knockout mice, learning and memory, synaptic plasticity, long-term potentiation, hippocampal CA1, object recognition, Barnes maze, fear conditioning, prefrontal cortex, amygdala, cognitive impairment
- MeSH terms
- Analysis of Variance, Animals, Cognition Disorders, Conditioning, Psychological, Fear, Hippocampus, Neuropsychological Tests, Receptors, Histamine H1, Receptors, Histamine H2, Long-Term Potentiation, Mice, Knockout, Maze Learning, Mice
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