The microglial phagocytic role with specific plaque types in the Alzheimer disease brain
Abstract
Alzheimer disease (AD) involves glial inflammation associated with amyloid plaques. The role of the microglial cells in the AD brain is controversial, as it remains unclear if the microglia form the amyloid fibrils of plaques or react to them in a macrophage-phagocytic role. Also, it is not known why microglia are preferentially associated with some amyloid plaque types. This review will provide substantial evidence to support the phagocytic role of microglia in the brain as well as explain why microglia are generally associated with specific plaque types that may be explained through their unique mechanisms of formation. In summary, the data presented suggests that plaque associated microglial activation is typically subsequent to specific amyloid plaque formations in the AD brain.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Microglial cells play pivotal role in maintaining immunoproteostasis through phagocytosis and degradation of misfolded proteins, their protective function is inseparably associated with immune activation exerting a chronic, potentially harmful effect on the regional milieu of neuronal networks.
“Though microglial cells play pivotal role in maintaining immunoproteostasis through phagocytosis and degradation of misfolded proteins, their protective function is inseparably associated with immune activation exerting a chronic, potentially harmful effect on the regional milieu of neuronal networks [35, 37–39].”
From APOE Genotype Differentially Modulates Effects of Anti-Aβ, Passive Immunization in APP Transgenic Mice (2017) · cites this paper as [38]
Glia, microglia, and astrocyte activations are associated with cerebral amyloid deposits necessary for phagocytic activity induction.
“Glia, microglia, and astrocyte activations are associated with cerebral amyloid deposits necessary for phagocytic activity induction (D'Andrea et al., 2004).”
From Arbovirus infection increases the risk for the development of neurodegenerative disease pathology in the murine model (2024) · cites this paper as D'Andrea et al., 2004
Plaque-associated microglia contain intracellular Aβ, show proinflammatory morphological changes, and have increased proinflammatory markers including MHC II, CD36, IL-1, IL-6, and TNF.
“They contain intracellular Aβ, suggesting phagocytosis31, show proinflammatory morphological changes such as somatic swelling and process shortening (Fig. 2c), and have increased proinflammatory markers including major histocompatibility complex II, CD36, IL-1, IL-6, and TNF32,33.”
From Microglia in neurodegeneration (2018) · cites this paper as [31]
The citation lists haven’t been fetched yet
References 71 · Cited by 215
- Authors
- D’Andrea, M. R., Cole, G. M., & Ard, M. D.
- Affiliations
- Janssen Research & Development (United States) (US)
- University of California, Los Angeles (US)
- University of Mississippi Medical Center (US)
- Corresponding author
- D’Andrea, Michael R
- ORCID
- Cole, Gregory M
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2004-05
- Volume
- 25
- Issue
- 5
- Pages
- 675-683
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2146550933
- Cited by
- 215
- References
- 71
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 9 · 2023: 10 · 2022: 10 · 2021: 9 · 2020: 9 · 2019: 8 · 2018: 9 · 2017: 7 · 2016: 10 · 2015: 12 · 2014: 16 · 2013: 10 · 2012: 5
- FWCI
- 7.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, microglia, phagocytosis, amyloid plaques, plaque type, microglial activation, glial inflammation, amyloid fibril formation, plaque-associated microglia
- MeSH terms
- Alzheimer Disease, Animals, Brain, Humans, Models, Biological, Phagocytosis, Microglia, Plaque, Amyloid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
