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Age-related glutamate and glutamine concentration changes in normal human brain: 1H MR spectroscopy study at 4 T
Open accessAbstract
Proton magnetic resonance spectroscopy was performed at 4 T to determine effects of age, region and gender on glutamate and glutamine in the normal human brain. Furthermore, glutamate and glutamine alterations with age were tested for correlations with other cerebral metabolites. Two 8 cm3 volumes were selected in corona radiata and mesial motor cortex in normal subjects (N = 24) between 24 and 68 years old. Older subjects had lower glutamate concentration in the motor cortex compared to younger subjects (p < 0.001). In corona radiata, older subjects demonstrated a trend in higher glutamine compared to younger subjects (p = 0.05). Glutamate in the motor cortex was positively correlated with glutamine, N-acetyl aspartate and creatine. Reduced glutamate and N-acetyl aspartate in the motor cortex is consistent with neuronal loss/shrinkage with age. In conclusion, different patterns in association with normal aging in these brain regions were detected in this study.
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“There is evidence though that glutamate changes with age in the healthy brain.20”
From Glutamate in Schizophrenia: A Focused Review and Meta-Analysis of 1H-MRS Studies (2013) · cites this paper as [20]
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“It has beensuggested that glutamatelevelsdecrease with age in healthyindividuals, 20”
From Glutamate in Schizophrenia: A Focused Review and Meta-Analysis of 1H-MRS Studies (2013) · cites this paper as [20]
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Metadata
- Authors
- Kaiser, L. G., Schuff, N., Cashdollar, N., & Weiner, M. W.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Kaiser, Lana G.
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2005-05
- Volume
- 26
- Issue
- 5
- Pages
- 665-672
- ISSN
- 0197-4580 (ISSN-L)
- PMC
- PMC2443746
- OpenAlex
- W1998855584
- Cited by
- 251
- References
- 43
- Citations by year
- 2026: 6 · 2025: 15 · 2024: 15 · 2023: 12 · 2022: 14 · 2021: 16 · 2020: 13 · 2019: 14 · 2018: 14 · 2017: 18 · 2016: 10 · 2015: 19 · 2014: 22 · 2013: 10 · 2012: 11
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (P50AG023501)
- National Institute of Neurological Disorders and Stroke (R01 NS 30321, F32 NS43153, F32NS043153)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- glutamate, glutamine, brain aging, normal human brain, motor cortex, corona radiata, N-acetylaspartate, creatine, brain metabolites, neuronal loss, age-related changes, 1H NMR
- MeSH terms
- Adult, Aged, Aging, Analysis of Variance, Aspartic Acid, Brain Chemistry, Creatine, Female, Glutamine, Humans, Male, Middle Aged, Motor Cortex, Magnetic Resonance Spectroscopy, Protons, Statistics as Topic, Glutamic Acid
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