Genetic association of low density lipoprotein receptor and Alzheimer's disease
Abstract
The low density lipoprotein receptor (LDLR) is an attractive candidate gene for genetic association with Alzheimer's disease (AD) because: (i) the LDLR is an apolipoprotein E (apoE) receptor, alleles of which have been associated with AD, (ii) LDLR resides at chromosome 19p13.3 within a region linked to AD, and (iii) LDLR modulates the homeostasis of cholesterol, which itself appears associated with AD. Therefore, we evaluated whether LDLR haplotypes alter the odds of AD by performing an association study examining three LDLR single nucleotide polymorphisms (SNPs) in 118 AD patients and 133 non-AD subjects. LDLR genotypes were obtained by TaqMan allelic discrimination assays. Although individual LDLR SNPs were not associated with AD, analyses of unambiguous haplotypes suggested the hypothesis that the 211 LDLR haplotype was associated with reduced odds of AD. We then evaluated this hypothesis in a second study cohort, i.e., the Religious Orders Study. These results supported the hypothesis that the 211 LDLR haplotype is associated with reduced odds of AD. Moreover, these data suggested further associations between LDLR variants and AD. Thus, LDLR variants appear significantly associated with AD and merit additional study.
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Several studies reported that a few single-nucleotide polymorphisms (SNPs) in LDLR gene are associated with the risk of developing AD in case-control studies.
“Several studies reported that a few single-nucleotide polymorphisms (SNPs) in LDLR gene are associated with the risk of developing AD in case-control studies (Cheng et al., 2005; Gopalraj et al., 2005; Retz et al., 2001).”
From Overexpression of Low-Density Lipoprotein Receptor in the Brain Markedly Inhibits Amyloid Deposition and Increases Extracellular Aβ Clearance (2009) · cites this paper as Gopalraj et al., 2005
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Kim, J., Castellano, J. M., Jiang, H., Basak, J. M., Parsadanian, M., Pham, V., Mason, S. M., Paul, S. M., & Holtzman, D. M. (2009) · Neuron · doi:10.1016/j.neuron.2009.11.013 · Cited by 274 · see citing works
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Bocarsly, M. E., Fasolino, M., Kane, G. A., LaMarca, E. A., Kirschen, G. W., Karatsoreos, I. N., McEwen, B. S., & Gould, E. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1511593112 · Cited by 250 · see citing works
- Authors
- Gopalraj, R. K., Zhu, H., Kelly, J. F., Mendiondo, M., Pulliam, J. F., Bennett, D. A., & Estus, S.
- Affiliations
- University of Kentucky (US)
- Rush University Medical Center (US)
- Corresponding author
- Estus, Steven
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2005-01
- Volume
- 26
- Issue
- 1
- Pages
- 1-7
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2077592857
- Cited by
- 51
- References
- 0
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 5 · 2018: 2 · 2017: 1 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 4
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (2P50AG05144-17, P50AG005144, R01AG021545, R01AG015819, P30AG010161, R01AG021362)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- LDL receptor, Alzheimer's disease, genetic association, single nucleotide polymorphisms, apolipoprotein E receptor, cholesterol homeostasis, Religious Orders Study, candidate genes
- MeSH terms
- Aged, Aged, 80 and over, Alleles, Alzheimer Disease, Exons, Female, Gene Frequency, Genotype, Humans, Genetic Linkage, Male, Receptors, LDL, Genetic Variation, Case-Control Studies, Polymorphism, Single Nucleotide
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