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The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Intact spatial learning in adult Tg2576 mice

Bizon, Jennifer, Prescott, Sonya, Nicolle, Michelle M.·2007·Neurobiology of Aging
DOI 10.1016/j.neurobiolaging.2006.01.004
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Abstract

Tg2576 mice, a transgenic model of amyloid pathology associated with Alzheimer's disease (AD), develop measurable levels of soluble amyloid beta1-40 and 1-42 by 6 months of age and amyloid plaque deposition in cortex, hippocampus and amygdala by 10 months of age. To investigate whether non-hippocampal learning strategies would predominate coincident with the age-related increase in Abeta load in the hippocampal region, we measured learning strategies in the T-maze and a redundant cued version of the water maze. Each of these tasks can be solved using either hippocampal or non-hippocampal learning strategies and has proved sensitive to hippocampal disruption in other settings. The results revealed subtle differences in T-maze and water maze performance in Tg2576 mice compared to controls. Surprisingly, however, Tg2576 mice were not impaired relative to non-transgenic littermates on any measures of hippocampal dependent behavior assessed in these tasks. These data suggest that the medial temporal lobe retains considerable function in 15-month-old Tg2576 mice despite significant Abeta pathology.

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Crossref · 10.1016/j.neurobiolaging.2006.01.004

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4 of 4 references verified0 citation errors · 0 not checkable

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  • Defective spatial learning and memory are known to be early symptoms of Alzheimer's disease.

    “Defective spatial learning and memory are known to be early symptoms of AD (Middei et al., 2006; Bizon et al., 2007; Good and Hale, 2007; Reed et al., 2010).”

    From VPS35 haploinsufficiency increases Alzheimer’s disease neuropathology (2011) · cites this paper as Bizon et al., 2007

  • Tg2576 mice normally develop AD-like phenotypes, including cognitive deficits and Aβ deposits, at age at least 10 mo or older.

    “Tg2576 mice normally develop AD-like phenotypes, including cognitive deficits and Aβ deposits, at the age of at least 10 mo or older (Chapman et al., 1999; Middei et al., 2006; Bizon et al., 2007).”

    From VPS35 haploinsufficiency increases Alzheimer’s disease neuropathology (2011) · cites this paper as Bizon et al., 2007

Citations

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Research works printed but not linked: 30

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Metadata

Authors
Bizon, J., Prescott, S., & Nicolle, M. M.
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
2007-03
Volume
28
Issue
3
Pages
440-446
ISSN
0197-4580
DOI
10.1016/j.neurobiolaging.2006.01.004
Cited by
23
References
4
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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