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Cited by 111Dementia and Cognitive Impairment ResearchParkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Prodromal clinical manifestations of neuropathologically confirmed Lewy body disease

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Jicha, G.A., Schmitt, F.A., Abner, E., Nelson, P.T., Cooper, G.E., Smith, C.D., Markesbery, W.R.·2010·Neurobiology of Aging
DOI 10.1016/j.neurobiolaging.2008.09.017PMC PMC2891418
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Abstract

The mild cognitive impairment (MCI) stage of dementia with Lewy bodies (MCI-DLB) has not yet been defined, but is likely to differ in the MCI stage of Alzheimer's disease (MCI-AD). To determine whether clinical features distinguish MCI-DLB and MCI-AD, 9 cases of neuropathologically confirmed MCI-DLB and 12 cases of MCI-AD were compared. No significant differences were found between MCI-DLB and MCI-AD cases in age at death, gender, ApoE status, education, time followed while clinically normal, or duration of MCI. MCI-DLB and MCI-AD cases differed clinically in the expression of Parkinsonism (P=0.012), provoked hallucinations or delirium (P=0.042), or the presence of any of these noncognitive symptoms of DLB (P<0.0001). Letter fluency (P=0.007) was significantly lower and Wechsler Logical Memory I (P=0.019) was significantly higher in MCI-DLB compared to MCI-AD cases. These data demonstrate the feasibility of differentiating underlying pathologic processes responsible for cognitive decline in the preclinical disease state and suggest that further refinement in diagnostic criteria may allow more accurate early detection of prodromal DLB and AD.

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References 51 · Cited by 111

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Authors
Jicha, G. A., Schmitt, F. A., Abner, E., Nelson, P. T., Cooper, G. E., Smith, C. D., & Markesbery, W. R.
Affiliations
University of Kentucky (US)
Corresponding author
Jicha, G.A.
ORCID
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
2010-10
Volume
31
Issue
10
Pages
1805-1813
ISSN
0197-4580 (ISSN-L)
DOI
10.1016/j.neurobiolaging.2008.09.017
PMC
PMC2891418
OpenAlex
W2075686321
Cited by
111
References
51
Citations by year
2026: 3 · 2025: 6 · 2024: 8 · 2023: 6 · 2022: 4 · 2021: 3 · 2020: 9 · 2019: 5 · 2018: 5 · 2017: 6 · 2016: 7 · 2015: 4 · 2014: 12 · 2013: 11 · 2012: 5
FWCI
3.98
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neurobiology of Aging (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute on Aging (P30AG028383)
  • National Institute of Neurological Disorders and Stroke (K08NS050110)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
dementia with Lewy bodies, mild cognitive impairment, Alzheimer's disease, prodromal Alzheimer's disease, parkinsonism, hallucinations, delirium, phonemic fluency, memory, differential diagnosis, early detection, diagnostic criteria
MeSH terms
Aged, Aged, 80 and over, Apolipoproteins E, Cognition Disorders, Delirium, Dementia, Educational Status, Female, Hallucinations, Humans, Male, Neuropsychological Tests, Parkinson Disease, Retrospective Studies, Cohort Studies, Lewy Body Disease

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