Respiratory chain deficiency in aged spinal motor neurons
Open accessAbstract
Sarcopenia, muscle wasting, and strength decline with age, is an important cause of loss of mobility in the elderly individuals. The underlying mechanisms are uncertain but likely to involve defects of motor nerve, neuromuscular junction, and muscle. Loss of motor neurons with age and subsequent denervation of skeletal muscle has been recognized as one of the contributing factors. This study investigated aspects of mitochondrial biology in spinal motor neurons from elderly subjects. We found that protein components of complex I of mitochondrial respiratory chain were reduced or absent in a proportion of aged motor neurons-a phenomenon not observed in fetal tissue. Further investigation showed that complex I-deficient cells had reduced mitochondrial DNA content and smaller soma size. We propose that mitochondrial dysfunction in these motor neurons could lead to the cell loss and ultimately denervation of muscle fibers.
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Loss of mitochondrial function with aging is shared by muscle cells and motor neurons.
“It is interesting that a loss of mitochondria function with aging is a mechanism that is shared by both muscle cells (18, 63) and motor neurons (123).”
From Mitochondria initiate and regulate sarcopenia (2017) · cites this paper as [123]
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References 46 · Cited by 41
- Authors
- Rygiel, K. A., Grady, J. P., & Turnbull, D. M.
- Affiliations
- Wellcome Centre for Mitochondrial Research (GB)
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 35
- Issue
- 10
- Pages
- 2230-2238
- ISSN
- 0197-4580 (ISSN-L)
- PMC
- PMC4099519
- OpenAlex
- W2069546567
- Cited by
- 41
- References
- 46
- Citations by year
- 2026: 5 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 10 · 2020: 3 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 6 · 2015: 3 · 2014: 1
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neurobiology of Aging (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity) (cc-by)
- Funders
- Medical Research Council (G0400074, G0700718)
- Wellcome Trust (GR082557)
- Newcastle upon Tyne Hospitals NHS Foundation Trust
- Economic and Social Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- respiratory chain deficiency, spinal motoneurons, aging, sarcopenia, mitochondrial complex I, mitochondrial dysfunction, mitochondrial DNA content, motor neuron degeneration, denervation, skeletal muscle atrophy, soma size
- MeSH terms
- Aged, Aged, 80 and over, Aging, DNA, Mitochondrial, Female, Humans, Male, Motor Neurons, Spinal Cord, Mitochondrial Diseases, Electron Transport Complex I, Sarcopenia
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