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Cited by 155Dementia and Cognitive Impairment ResearchParkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Pattern of brain atrophy rates in autopsy-confirmed dementia with Lewy bodies

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Nedelska, Zuzana, Ferman, Tanis J., Boeve, Bradley F., Przybelski, Scott A., Lesnick, Timothy G., Murray, Melissa E., Gunter, Jeffrey L., Senjem, Matthew L. +10 more·2015·Neurobiology of Aging
DOI 10.1016/j.neurobiolaging.2014.07.005PMC PMC4268128
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Abstract

Dementia with Lewy bodies (DLB) is characterized by preserved whole brain and medial temporal lobe volumes compared with Alzheimer's disease dementia (AD) on magnetic resonance imaging. However, frequently coexistent AD-type pathology may influence the pattern of regional brain atrophy rates in DLB patients. We investigated the pattern and magnitude of the atrophy rates from 2 serial MRIs in autopsy-confirmed DLB patients (n = 20) and mixed DLB/AD patients (n = 22), compared with AD (n = 30) and elderly nondemented control subjects (n = 15), followed antemortem. DLB patients without significant AD-type pathology were characterized by lower global and regional rates of atrophy, similar to control subjects. The mixed DLB/AD patients displayed greater atrophy rates in the whole brain, temporoparietal cortices, hippocampus and amygdala, and ventricle expansion, similar to AD patients. In the DLB and DLB/AD patients, the atrophy rates correlated with Braak neurofibrillary tangle stage, cognitive decline, and progression of motor symptoms. Global and regional atrophy rates are associated with AD-type pathology in DLB, and these rates can be used as biomarkers of AD progression in patients with LB pathology.

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Authors
Nedelska, Z., Ferman, T. J., Boeve, B. F., Przybelski, S. A., Lesnick, T. G., Murray, M. E., Gunter, J. L., Senjem, M. L., Vemuri, P., Smith, G. E., Geda, Y. E., Graff-Radford, J., Knopman, D. S., Petersen, R. C., Parisi, J. E., Dickson, D. W., Jack, C. R., & Kantarci, K.
Affiliations
  • Mayo Clinic (US)
  • Mayo Clinic in Florida (US)
Corresponding author
Kantarci, Kejal
ORCID
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
2015-01
Volume
36
Issue
1
Pages
452-461
ISSN
0197-4580 (ISSN-L)
DOI
10.1016/j.neurobiolaging.2014.07.005
PMC
PMC4268128
OpenAlex
W2040670498
Cited by
155
References
75
Citations by year
2026: 6 · 2025: 15 · 2024: 13 · 2023: 6 · 2022: 16 · 2021: 18 · 2020: 12 · 2019: 16 · 2018: 13 · 2017: 14 · 2016: 14 · 2015: 10 · 2014: 1
FWCI
9.93
Type
journal article
Language
en
Open access
Licence
Locations
  • Neurobiology of Aging (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (P50-AG16574/P1, R01AG040042, R01-AG015866, R01-AG11378, P50-AG16574)
  • Mangurian Foundation
  • CTSA (UL1 TR000135)
  • National Center for Advancing Translational Sciences, United States
  • Grant Agency of Charles University in Prague (624012)
  • European Social Fund within the project Young Talent Incubator II (reg. CZ.1.07/2.3.00/20.0117)
  • State Budget of the Czech Republic
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
dementia with Lewy bodies, brain atrophy rate, Alzheimer's disease pathology, regional brain atrophy, hippocampal atrophy, amygdala atrophy, ventriculomegaly, cognitive decline, MRI biomarkers
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Amygdala, Atrophy, Autopsy, Brain, Cognition, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Organ Size, Parietal Lobe, Temporal Lobe, Biomarkers, Neurofibrillary Tangles, Disease Progression, Lewy Body Disease

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