Early disruption of parvalbumin expression and perineuronal nets in the hippocampus of the Tg2576 mouse model of Alzheimer's disease can be rescued by enriched environment
Abstract
Recent findings show that parvalbumin (PV) interneuron function is impaired in Alzheimer's disease (AD), and that this impairment in PV function can be linked to network dysfunction and memory deficits. PV cells are often associated with a specific extracellular matrix, the perineuronal net (PNN). PNNs are believed to protect PV cell integrity, and whether the amyloidopathy affects PNNs remains unclear. Here, we evaluated the number of PV cells with and without PNNs in the hippocampus of the Tg2576 mouse model of AD at different stages of the disease. We show a deficit of PV+ and/or PV+/PNN+ cells in the areas CA1, CA2, and CA3 in Tg2576 as young as 3 months of age. Importantly, transient exposure to an enriched environment, which has proven long-lasting beneficial effects on memory in AD subjects, rescues the PV/PNN cell number deficits. We conclude that cognitive improvements induced by enriched environment in AD mouse models could be supported by a remodeling of hippocampal PV cell network and their PNNs.
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Reduced PNN expression has been shown in Tg2576 mice.
“Furthermore, reduced PNN expression had recently shown in Tg2576 mice (Cattaud et al., 2018).”
From Disrupted structural connectivity in ArcAβ mouse model of Aβ amyloidosis (2020) · cites this paper as Cattaud et al., 2018
Whether perineuronal nets are altered in Alzheimer's disease remains controversial.
“but whether PNNs are altered in AD remains controversial.”
From Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain (2020) · cites this paper as [41]
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References 88 · Cited by 88
- Authors
- Cattaud, V., Bezzina, C., Rey, C. C., Lejards, C., Dahan, L., & Verret, L.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Verret, Laure
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2018-12
- Volume
- 72
- Pages
- 147-158
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2889564243
- Cited by
- 88
- References
- 88
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 20 · 2023: 11 · 2022: 14 · 2021: 9 · 2020: 15 · 2019: 3 · 2018: 1
- FWCI
- 4.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Centre National de la Recherche Scientifique
- University of Toulouse
- Fondation Fyssen
- Association France Alzheimer
- Institut Universitaire de France
- Fondation Vaincre Alzheimer (15033, 2015)
- Agence Régionale de Santé
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- parvalbumin interneurons, perineuronal nets, Alzheimer's disease, environmental enrichment, hippocampus, amyloid pathology, interneuron loss, extracellular matrix
- MeSH terms
- Age Factors, Aging, Alzheimer Disease, Animals, Disease Models, Animal, Environment, Extracellular Matrix, Female, Hippocampus, Interneurons, Mice, Inbred C57BL, Mice, Transgenic, Parvalbumins, Amyloid beta-Peptides, Mice
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