The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
Influence of the stress hormone cortisol on fear conditioning in humans: Evidence for sex differences in the response of the prefrontal cortex
Abstract
The stress hormone cortisol is known to influence declarative memory and associative learning. In animals, stress has often been reported to have opposing effects on memory and learning in males and females. In humans, the effects of cortisol have mainly been studied at the behavioral level. The aim of the present experiment was to characterize the effects of a single cortisol dose (30 mg) on the hemodynamic correlates of fear conditioning. In a double-blind group comparison study subjects (17 females and 17 males) received 30 mg cortisol or placebo orally before participating in a discriminative fear conditioning paradigm. Results revealed that cortisol impaired electrodermal signs of learning (the first interval response) in males, while no conditioned SCRs emerged for the females independent of treatment. fMRI results showed that cortisol reduced activity for the CS+ > CS- comparison in the anterior cingulate, the lateral orbitofrontal cortex and the medial prefrontal cortex in males. Opposite findings (increase in these regions under cortisol) were detected in females. In addition, cortisol reduced the habituation in the CS+ > CS- contrast in the dorsolateral prefrontal cortex independent of sex. Finally, cortisol also modified the response to the electric shock (the UCS) by enhancing the activity of the anterior as well as the posterior cingulate. In sum, these findings demonstrate that in humans cortisol mostly influences prefrontal brain activation during fear conditioning and that these effects appear to be modulated by sex.
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“The SRS modulates learning in a number of different ways: HPA and autonomic profiles have been associated with individual differences in cognitive functioning (e.g., Staton et al., 2009), memory (e.g., Stark et al., 2006), and self-regulation/executive function (e.g., Blair et al., 2005; Shoal et al., 2003; Williams et al., 2009)”
From The Adaptive Calibration Model of stress responsivity (2011) · cites this paper as Stark et al., 2006
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The Neurocircuitry of Fear, Stress, and Anxiety Disorders
Shin, L. M., & Liberzon, I. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.83 · Cited by 2,083
Lupien, S. J., Maheu, F., Tu, M., Fiocco, A., & Schramek, T. E. (2007) · Brain and Cognition · doi:10.1016/j.bandc.2007.02.007 · Cited by 1,474
The Adaptive Calibration Model of stress responsivity
Del Giudice, M., Ellis, B. J., & Shirtcliff, E. A. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.11.007 · Cited by 1,373
Lonsdorf, T. B., Menz, M. M., Andreatta, M., Fullana, M. A., Golkar, A., Haaker, J., Heitland, I., Hermann, A., Kuhn, M., Kruse, O., et al. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.02.026 · Cited by 837
Neural signatures of human fear conditioning: an updated and extended meta-analysis of fMRI studies
Fullana, M. A., Harrison, B. J., Soriano-Mas, C., Vervliet, B., Cardoner, N., Àvila-Parcet, A., & Radua, J. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.88 · Cited by 702
Metadata
- Authors
- Stark, R., Wolf, O. T., Tabbert, K., Kagerer, S., Zimmermann, M., Kirsch, P., Schienle, A., & Vaitl, D.
- Affiliations
- Justus-Liebig-Universität Gießen (DE)
- Bielefeld University (DE)
- Corresponding author
- Stark, Rudolf
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2006-09
- Volume
- 32
- Issue
- 3
- Pages
- 1290-1298
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W1971752570
- Cited by
- 167
- References
- 70
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 3 · 2019: 6 · 2018: 7 · 2017: 7 · 2016: 13 · 2015: 7 · 2014: 14 · 2013: 17 · 2012: 13
- FWCI
- 4.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- cortisol, fear conditioning, sex differences, prefrontal cortex, stress hormones, electrodermal activity, anterior cingulate cortex, orbitofrontal cortex, dorsolateral prefrontal cortex, habituation, learning and memory
- MeSH terms
- Adult, Conditioning, Psychological, Double-Blind Method, Fear, Female, Galvanic Skin Response, Hemodynamics, Humans, Hydrocortisone, Magnetic Resonance Imaging, Male, Photic Stimulation, Sex Characteristics, Prefrontal Cortex
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