T1ρ MRI of Alzheimer's disease
Open accessAbstract
Alzheimer's disease (AD) is the most common form of dementia in the elderly. Classic symptoms of the disease include memory loss and confusion associated with the hallmark neuro-pathologic lesions of neurofibrillary tangles (NFT) and senile plaques (SP) and their sequelae, gray matter atrophy. Volumetric assessment methods measure tissue atrophy, which typically follows early biochemical changes. An alternate MRI contrast mechanism to visualize the early pathological changes is T1rho (or "T-1-rho"), the spin lattice relaxation time constant in the rotating frame, which determines the decay of the transverse magnetization in the presence of a "spin-lock" radio-frequency field. Macromolecular changes (in plaques and tangles) that accompany early AD are expected to alter bulk water T1rho relaxation times. In this work, we measure T1rho MRI on patients with clinically diagnosed AD, MCI and in age-matched cognitively normal control subjects in order to compare T1rho values with changes in brain volume in the same regions of the brain and demonstrate that T1rho can potentially constitute an important biomarker of AD.
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Previous studies have shown higher T1ρ value in the medial temporal lobe of AD compared to those of MCI and control.
“Previous studies have shown higher T1ρ value in the medial temporal lobe (MTL) of AD compared to those of mild cognitive impairment (MCI) and control (Haris et al., 2011; Borthakur et al., 2008).”
From T1rho MRI and CSF biomarkers in diagnosis of Alzheimer's disease (2015) · cites this paper as Borthakur et al., 2008
Cites
Lee, V. M.-Y., Goedert, M., & Trojanowski, J. Q. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1121 · Cited by 2,480 · see citing works
Self-citationPrediction of AD with MRI-based hippocampal volume in mild cognitive impairment
Jack, C. R., Petersen, R. C., Xu, Y. C., O’Brien, P. C., Smith, G. E., Ivnik, R. J., Boeve, B. F., Waring, S. C., Tangalos, E. G., & Kokmen, E. (1999) · Neurology · doi:10.1212/wnl.52.7.1397 · Cited by 1,404 · see citing works
Comparison of different MRI brain atrophy rate measures with clinical disease progression in AD
Jack, C. R., Shiung, M. M., Gunter, J. L., O’Brien, P. C., Weigand, S. D., Knopman, D. S., Boeve, B. F., Ivnik, R. J., Smith, G. E., Cha, R. H., et al. (2004) · Neurology · doi:10.1212/01.wnl.0000110315.26026.ef · Cited by 827 · cited 1× · see citing works
“These measurements were performed in the medial temporal lobe region of the brain that is primarily associated with AD pathology (DeCarli et al., 1990; Sandor et al., 1992; Jack et al., 2004).”
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T1rho MRI and CSF biomarkers in diagnosis of Alzheimer's disease
Haris, M., Yadav, S. K., Rizwan, A., Singh, A., Cai, K., Kaura, D., Wang, E., Davatzikos, C., Trojanowski, J. Q., Melhem, E. R., et al. (2015) · NeuroImage: Clinical · doi:10.1016/j.nicl.2015.02.016 · Cited by 33 · see citing works
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- Authors
- Borthakur, A., Sochor, M., Davatzikos, C., Trojanowski, J. Q., & Clark, C. M.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Borthakur, Arijitt
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 41
- Issue
- 4
- Pages
- 1199-1205
- ISSN
- 1053-8119 (ISSN-L)
- PMC
- PMC2473861
- OpenAlex
- W2095016383
- Cited by
- 84
- References
- 3
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 6 · 2022: 3 · 2021: 9 · 2020: 9 · 2018: 3 · 2017: 5 · 2016: 7 · 2015: 9 · 2014: 8 · 2013: 3 · 2012: 6
- FWCI
- 2.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (R01AG014971)
- National Center for Research Resources (RR02305, P41RR002305)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, T1rho MRI, spin-lattice relaxation, neurofibrillary tangles, amyloid plaques, gray matter atrophy, mild cognitive impairment, brain volume, early pathological changes, biomarkers
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Cognition Disorders, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Temporal Lobe
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