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Cited by 79Advanced Neuroimaging Techniques and ApplicationsAdvanced MRI Techniques and ApplicationsFunctional Brain Connectivity Studies

How does angular resolution affect diffusion imaging measures?

Open access
Zhan, Liang, Leow, Alex D., Jahanshad, Neda, Chiang, Ming-Chang, Barysheva, Marina, Lee, Agatha D., Toga, Arthur W., McMahon, Katie L. +3 more·2010·NeuroImage
DOI 10.1016/j.neuroimage.2009.09.057PMC PMC3086646
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Abstract

A key question in diffusion imaging is how many diffusion-weighted images suffice to provide adequate signal-to-noise ratio (SNR) for studies of fiber integrity. Motion, physiological effects, and scan duration all affect the achievable SNR in real brain images, making theoretical studies and simulations only partially useful. We therefore scanned 50 healthy adults with 105-gradient high-angular resolution diffusion imaging (HARDI) at 4T. From gradient image subsets of varying size (6<or=N<or=94) that optimized a spherical angular distribution energy, we created SNR plots (versus gradient numbers) for seven common diffusion anisotropy indices: fractional and relative anisotropy (FA, RA), mean diffusivity (MD), volume ratio (VR), geodesic anisotropy (GA), its hyperbolic tangent (tGA), and generalized fractional anisotropy (GFA). SNR, defined in a region of interest in the corpus callosum, was near-maximal with 58, 66, and 62 gradients for MD, FA, and RA, respectively, and with about 55 gradients for GA and tGA. For VR and GFA, SNR increased rapidly with more gradients. SNR was optimized when the ratio of diffusion-sensitized to non-sensitized images was 9.13 for GA and tGA, 10.57 for FA, 9.17 for RA, and 26 for MD and VR. In orientation density functions modeling the HARDI signal as a continuous mixture of tensors, the diffusion profile reconstruction accuracy rose rapidly with additional gradients. These plots may help in making trade-off decisions when designing diffusion imaging protocols.

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  • Differences in dMRI acquisition parameters, including vendor, voxel size, and angular resolution, are known to affect derived dMRI measures.

    “differences in dMRI acquisition parameters, including vendor, voxel size, and angular resolution, are known to affect derived dMRI measures (Alexander et al., 2001; Cercignani et al., 2003; Zhan et al., 2010; Zhu et al., 2011).”

    From Diffusion MRI Indices and Their Relation to Cognitive Impairment in Brain Aging: The Updated Multi-protocol Approach in ADNI3 (2019) · cites this paper as Zhan et al., 2010

    The Conclusions report that the number of diffusion gradients affects the signal-to-noise ratio of derived measures, supporting the angular-resolution part of the claim. They also say achievable SNR depends on the scanner and spatial resolution, but do not establish that vendor or voxel-size differences affect derived dMRI measures. No page numbers are available in our copy. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

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Authors
Zhan, L., Leow, A. D., Jahanshad, N., Chiang, M.-C., Barysheva, M., Lee, A. D., Toga, A. W., McMahon, K. L., de Zubicaray, G. I., Wright, M. J., & Thompson, P. M.
Affiliations
  • University of California, Los Angeles (US)
  • The University of Queensland (AU)
  • QIMR Berghofer Medical Research Institute (AU)
Corresponding author
Thompson, Paul M.
ORCID
Venue
NeuroImage
Publisher
Elsevier BV
Published
2010-01
Volume
49
Issue
2
Pages
1357-1371
ISSN
1053-8119 (ISSN-L)
DOI
10.1016/j.neuroimage.2009.09.057
PMC
PMC3086646
OpenAlex
W2094269283
Cited by
79
References
53
Citations by year
2026: 1 · 2025: 4 · 2024: 3 · 2023: 6 · 2022: 3 · 2021: 4 · 2020: 6 · 2019: 5 · 2018: 2 · 2017: 6 · 2016: 1 · 2015: 3 · 2014: 6 · 2013: 14 · 2012: 8
FWCI
3.78
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • NeuroImage (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • NIH (R01 HD050735, EB007813, EB008281, EB008432, HD050735, AG020098)
  • National Health and Medical Research Council, Australia (496682)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords
high angular resolution diffusion imaging, angular resolution, signal-to-noise ratio, diffusion-weighted imaging, fiber integrity, fractional anisotropy, generalized fractional anisotropy, mean diffusivity, volume ratio, corpus callosum, orientation density function
MeSH terms
Algorithms, Computer Simulation, Corpus Callosum, Diffusion, Female, Humans, Male, Models, Neurological, Anisotropy, Imaging, Three-Dimensional, Diffusion Magnetic Resonance Imaging, Young Adult

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